M. Asaliaru Komatsu

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R. Raja Singh, Susmita Kaushik, +6 authors Mark J. Czaja
Nature
2009

The intracellular storage and utilization of lipids are critical to maintain cellular energy homeostasis. During nutrient deprivation, cellular lipids stored as triglycerides in lipid droplets are… (More)

Autophagy: Renovation of Cells and Tissues

Autophagy is the major intracellular degradation system by which cytoplasmic materials are delivered to and degraded in the lysosome. However, the purpose of autophagy is not the simple elimination… (More)

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

M. Asaliaru Komatsu, Satoshi Waguri, +10 authors Tomoki Chiba
The Journal of cell biology
2005

Autophagy is a membrane-trafficking mechanism that delivers cytoplasmic constituents into the lysosome/vacuole for bulk protein degradation. This mechanism is involved in the preservation of… (More)

Loss of autophagy in the central nervous system causes neurodegeneration in mice.

M. Asaliaru Komatsu, Satoshi Waguri, +8 authors Keiji Tanaka
Nature
2006

Protein quality-control, especially the removal of proteins with aberrant structures, has an important role in maintaining the homeostasis of non-dividing neural cells. In addition to the… (More)

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.

Daniel J Klionsky, Hagai Abeliovich, +233 authors Russell L. Deter
Autophagy
2008

Research in autophagy continues to accelerate,(1) and as a result many new scientists are entering the field. Accordingly, it is important to establish a standard set of criteria for monitoring… (More)

Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice

M. Asaliaru Komatsu, Satoshi Waguri, +22 authors Keiji Tanaka
Cell
2007

Inactivation of constitutive autophagy results in formation of cytoplasmic protein inclusions and leads to liver injury and neurodegeneration, but the details of abnormalities related to impaired… (More)

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

M. Asaliaru Komatsu, Hirofumi Kurokawa, +16 authors Masayuki Yamamoto
Nature Cell Biology
2010

Impaired selective turnover of p62 by autophagy causes severe liver injury accompanied by the formation of p62-positive inclusions and upregulation of detoxifying enzymes. These phenotypes correspond… (More)

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

Noriyuki Matsuda, Shigeto Sato, +11 authors Keiji Tanaka
The Journal of cell biology
2010

Parkinson's disease (PD) is a prevalent neurodegenerative disorder. Recent identification of genes linked to familial forms of PD such as Parkin and PINK1 (PTEN-induced putative kinase 1) has… (More)

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.

Tatsuya Saitoh, Naonobu Fujita, +13 authors Shizuo Akira
Nature
2008

Systems for protein degradation are essential for tight control of the inflammatory immune response. Autophagy, a bulk degradation system that delivers cytoplasmic constituents into autolysosomes,… (More)

A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.

Vladimir Kirkin, Trond Lamark, +15 authors Terje Johansen
Molecular cell
2009

Autophagy is a catabolic process where cytosolic cellular components are delivered to the lysosome for degradation. Recent studies have indicated the existence of specific receptors, such as p62,… (More)

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