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OCT4B1, a novel spliced variant of OCT4, is highly expressed in gastric cancer and acts as an antiapoptotic factor
- M. Asadi, S. Mowla, F. Fathi, A. Aleyasin, Jamshid Asadzadeh, Y. Atlasi
- Biology, MedicineInternational journal of cancer
- 1 June 2011
The findings suggest that OCT4B1 has a potential role in tumorigenesis of Gastric cancer and candidates the variant as a new tumor marker with potential value in diagnosis and treatment of gastric cancer.
Altered expression of apoptotic genes in response to OCT4B1 suppression in human tumor cell lines
Investigating the effects of OCT4B1 suppression on the expression alteration of 84 genes involved in apoptotic pathway found an almost similar pattern of alteration in the expression profile of apoptotic genes in all three studied cell lines, following OCT4 B1 suppression.
Concomitant upregulation of nucleostemin and downregulation of Sox2 and Klf4 in gastric adenocarcinoma
Based on the results, NS overexpression seems to have a causative role in gastric tumorigenesis and/or progression, and it could be considered as a potential tumor marker for diagnosis, molecular classification, and molecular therapy of gastric adenocarcinoma.
A plausible anti-apoptotic role of up-regulated OCT4B1 in bladder tumors.
OCT4B1 can be regarded as a new tumor marker for detection, classification, and treatment of the bladder cancer, however, more experimental studies are needed to replicate the findings.
Differential expression of nucleostemin, a stem cell marker, and its variants in different types of brain tumors
- M. Malakootian, S. Mowla, H. Saberi, M. Asadi, Y. Atlasi, A. M. Shafaroudi
- Biology, MedicineMolecular carcinogenesis
- 1 September 2010
A significant reduction of NS expression along with a moderate blockade of the cell cycle in G2/M and S phases of NS‐siRNA treated cells is revealed, suggesting a potential role for NS in tumorogenesis of brain cancers.
The suppression effect of Ferula gummosa Boiss. extracts on cell proliferation through apoptosis induction in gastric cancer cell line
Abstract Background Ferula gummosa Boiss. (Barije) is an Iranian endemic plant growing in the northern mountainous regions. The gum extracted from the aerial parts of the plant has been traditionally…
A novel biosensor for liquid phase determination of glutathione and amoxicillin in biological and pharmaceutical samples using a ZnO/CNTs nanocomposite/catechol derivative modified electrode
- H. Karimi-Maleh, Fahimeh Tahernejad-Javazmi, Vinod K. Gupta, H. Ahmar, M. Asadi
- Materials Science
- 1 August 2014
Abstract In the present study, the use of a carbon paste electrode modified by 8,9-dihydroxy-7-methyl-12H-benzothiazolo[2,3-b]quinazolin-12-one (DMBQ) and ZnO/CNTs nanocomposite (DMBQ/ZnO/CNTs/CPE)…
Application of a modified graphene nanosheet paste electrode for voltammetric determination of methyldopa in urine and pharmaceutical formulation
- H. Beitollahi, S. Tajik, M. Asadi, P. Biparva
- Materials ScienceJournal of Analytical Science and Technology
- 28 May 2014
BackgroundElectrochemical sensors and biosensors for pharmaceutical, food, agricultural and environmental analyses have been growing rapidly due to electrochemical behavior of drugs and biomolecules…
MIAT lncRNA is overexpressed in breast cancer and its inhibition triggers senescence and G1 arrest in MCF7 cell line
The results suggest that MIAT involved in breast cancer progression and could be candidate as a novel tumor marker for diagnosis and treatment of breast cancer.
SNHG6 is upregulated in primary breast cancers and promotes cell cycle progression in breast cancer-derived cell lines
It is found that the expression of SNHG6 was significantly upregulated in primary high-grade and progesterone receptor (PR)-positive breast tumours and led to suppressed breast cancer cell proliferation by inducing apoptosis and senescence.