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Genetic Diversity within Cryptosporidium parvum and Related Cryptosporidium Species
  • Lihua Xiao, U. Morgan, +6 authors A. Lal
  • Biology, Medicine
  • Applied and Environmental Microbiology
  • 1 August 1999
A need for revision in the taxonomy and assessment of the zoonotic potential of some animal C. parvum isolates is indicated, because extensive genetic diversities were present among C. Parvum genotypes. Expand
A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium.
Use of cryptosporidium genomes has helped to identify promising therapeutic targets, and drugs are in development, but methods to assess the efficacy in vitro and in animals are not well standardised. Expand
Isolation of Cryptosporidium oocysts and sporozoites using discontinuous sucrose and isopycnic Percoll gradients.
Techniques for the large-scale isolation of Cryptosporidium oocysts and sporozoites, obtained from the feces of experimentally infected Holstein calves, were developed employing discontinuous sucroseExpand
Genetic polymorphism among Cryptosporidium parvum isolates: evidence of two distinct human transmission cycles.
The results of molecular analysis of 39 isolates of Cryptosporidium parvum from human and bovine sources in nine human outbreaks and from bovines from a wide geographic distribution support the occurrence of two distinct transmission cycles of C. parVum in humans. Expand
Genetic Diversity of Cryptosporidium spp. in Captive Reptiles
  • L. Xiao, U. Ryan, +10 authors A. Lal
  • Biology, Medicine
  • Applied and Environmental Microbiology
  • 1 February 2004
Sequence and biologic characterizations indicated that the desert monitor genotype was Cryptosporidium saurophilum, and two host-adapted C. serpentis genotypes were found in snakes and lizards. Expand
New Cryptosporidium Genotypes in HIV-Infected Persons
Using DNA sequencing and phylogenetic analysis, we identified four distinct Cryptosporidium genotypes in HIV-infected patients: genotype 1 (human), genotype 2 (bovine) Cryptosporidium parvum, aExpand
Differentiating human from animal isolates of Cryptosporidium parvum.
A polymerase chain reaction/restriction fragment length polymorphism method based on the thrombospondin-related anonymous protein 2 gene sequence can differentiate between the two genotypes of C. parvum and elucidate the transmission of infection to humans. Expand
Epidemiologic Studies of Cyclospora cayetanensis in Guatemala
In 1996 and 1997, cyclosporiasis outbreaks in North America were linked to eating Guatemalan raspberries. We conducted a study in health-care facilities and among raspberry farm workers, as well as aExpand
Occurrence of Cryptosporidium oocysts in sewage effluents and selected surface waters.
Sand filtration may reduce the concentrations of this parasite in waste waters, and since Cryptosporidium oocysts are frequently present in environmental waters, they could be responsible for waterborne outbreaks of disease. Expand
Effects of immune colostrum and orally administered antisporozoite monoclonal antibodies on the outcome of Cryptosporidium parvum infections in neonatal mice
A neonatal BALB/c mouse model of cryptosporidiosis was used to examine the potential passive transfer of immunity via immune colostrum and oral treatment with anticryptosporidial monoclonalExpand