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The interplay between cell signalling and the mevalonate pathway in cancer
- P. Mullen, Rosemary Yu, Joseph Longo, M. Archer, L. Penn
- Biology, Medicine
- Nature Reviews Cancer
- 26 August 2016
The mevalonate (MVA) pathway is an essential metabolic pathway that uses acetyl-CoA to produce sterols and isoprenoids that are integral to tumour growth and progression. In recent years, many… Expand
Middle Miocene kangaroos ( Macropodoidea: Marsupiala) from three localities in northern Australia, with a description of two new subfamilies.
Results of the Ray E. Lemley Expeditions, Part 1. The Allingham Formation and a new Pliocene vertebrate fauna from northern Queensland
New information about the Quaternary distribution of the thylacine (Marsupialia, Thylacinidae) in Australia
- M. Archer
Diabetes and Cancer
Epidemiologic evidence suggests that cancer incidence is associated with diabetes as well as certain diabetes risk factors and diabetes treatments. This consensus statement of experts assembled… Expand
Geraniol and beta-ionone inhibit proliferation, cell cycle progression, and cyclin-dependent kinase 2 activity in MCF-7 breast cancer cells independent of effects on HMG-CoA reductase activity.
- Robin E. Duncan, Dominic S Y Lau, A. El-Sohemy, M. Archer
- Biology, Medicine
- Biochemical pharmacology
- 1 November 2004
3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase catalyzes the formation of mevalonate, a precursor of cholesterol that is also required for cell proliferation. Mevalonate depletion results… Expand
Statins and Cancer Development
- Robin E. Duncan, A. El-Sohemy, M. Archer
- Cancer Epidemiology Biomarkers & Prevention
- 1 August 2005
There is epidemiologic evidence that the hydrophilic 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase inhibitor pravastatin increases the incidence of some extrahepatic cancers, although this… Expand
Susceptibility of lean and obese Zucker rats to tumorigenesis induced by N-methyl-N-nitrosourea.
To address the possible involvement of hyperinsulinemia in breast cancer development, we have examined the susceptibility of lean and obese Zucker rats to N-methyl-N-nitrosourea (MNU)-induced mammary… Expand
Effects of dietary conjugated linoleic acid on the expression of uncoupling proteins in mice and rats
CLA inhibits mammary cancer and reduces body fat accumulation in rodents. It is not known whether uncoupling proteins (UCP), which are modulators of energy balance and metabolism, play a role in… Expand