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Pharmacokinetics and tissue distribution of olanzapine in rats
The single dose pharmacokinetics of olanzapine in rats, following an oral dose and its distribution in the brain and other tissues after repeated oral and intra‐peritoneal (i.p.) administration, were… Expand
Field dependent transverse relaxation rate increase may be a specific measure of tissue iron stores
- G. Bartzokis, M. Aravagiri, W. Oldendorf, J. Mintz, S. Marder
- Chemistry, Medicine
- Magnetic resonance in medicine
- 1 April 1993
The degree to which MRI magnet field strength affects measured transverse relaxation rates (R2) defines a measure termed the field dependent R2 increase (FDRI). We report here the results of in vivo… Expand
Sex, Race, and Smoking Impact Olanzapine Exposure
Response to antipsychotics is highly variable, which may be due in part to differences in drug exposure. The goal of this study was to evaluate the magnitude and variability of concentration exposure… Expand
Plasma level monitoring of olanzapine in patients with schizophrenia: determination by high-performance liquid chromatography with electrochemical detection.
A sensitive high-performance liquid chromatography method with electrochemical detection for the determination of olanzapine in human plasma is described. Olanzapine from plasma samples was isolated… Expand
Clinical outcome following neuroleptic discontinuation in patients with remitted recent-onset schizophrenia.
- M. Gitlin, K. Nuechterlein, +5 authors M. Aravagiri
- The American journal of psychiatry
- 1 November 2001
OBJECTIVE The goal of this report was to examine the clinical course following neuroleptic discontinuation of patients with recent-onset schizophrenia who had been receiving maintenance antipsychotic… Expand
Brain, plasma and tissue pharmacokinetics of risperidone and 9-hydroxyrisperidone after separate oral administration to rats
Abstract.Rationale: Following an oral dose of risperidone (RSP), concentrations of its major metabolite 9-hydroxyrisperidone (9-OHRSP) were high in plasma and tissues but disproportionately lower in… Expand
Neuroleptic plasma levels.
- T. van Putten, S. Marder, W. Wirshing, M. Aravagiri, N. Chabert
- Psychology, Medicine
- Schizophrenia bulletin
There is enormous variation in plasma levels of most neuroleptics in patients on the same dose. Much of the past research on the relation between plasma levels of antipsychotic drugs and clinical… Expand
Plasma concentrations of risperidone and its 9-hydroxy metabolite and their relationship to dose in schizophrenic patients: simultaneous determination by a high performance liquid chromatography with…
A simple, sensitive and accurate method for the simultaneous determination of risperidone (RSP) and its 9-hydroxy metabolite (9-OH-RSP) in human plasma is described. The relationship between dose of… Expand
Effects of chronic haloperidol and clozapine treatment on neurotensin and c-fos mRNA in rat neostriatal subregions.
- K. Merchant, D. Dobie, F. Filloux, M. Totzke, M. Aravagiri, D. Dorsa
- The Journal of pharmacology and experimental…
- 1 October 1994
Previous studies have shown elevation of neurotensin neuromedin N (NT/N) and c-fos mRNA in the dorsolateral region of the rat neostriatum (DLSt) by acute administration of only typical antipsychotic… Expand
Simultaneous determination of clozapine and its N-desmethyl and N-oxide metabolites in plasma by liquid chromatography/electrospray tandem mass spectrometry and its application to plasma level…
- M. Aravagiri, S. Marder
- Chemistry, Medicine
- Journal of pharmaceutical and biomedical analysis
- 1 September 2001
A liquid chromatography tandem mass spectrometry (LC-MS-MS) assay method for the simultaneous determination of clozapine and its N-desmethyl (norclozapine) and N-oxide metabolites in human plasma is… Expand