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Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid
Using specialized linkage transduction, a single point mutation allele (S94A) within the putative target gene inhA was transferred in Mycobacterium tuberculosis and was sufficient to confer clinically relevant levels of resistance to isoniazid killing and inhibition of mycolic acid biosynthesis.
Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria.
Mitochondrial Phospholipid Hydroperoxide Glutathione Peroxidase Suppresses Apoptosis Mediated by a Mitochondrial Death Pathway*
- K. Nomura, H. Imai, T. Koumura, M. Arai, Y. Nakagawa
- Biology, ChemistryThe Journal of Biological Chemistry
- 8 October 1999
Hydperoxide, produced in mitochondria, is a major factor in apoptosis and that mitochondrial PHGPx might play a critical role as an anti-apoptotic agent in mitochondrial death pathways is suggested.
Lariatins, Novel Anti-mycobacterial Peptides with a Lasso Structure, Produced by Rhodococcus jostii K01-B0171
Two anti-mycobacterial peptides with a lasso structure, named lariatins A and B, were separated by HP-20 and ODS column chromatographies and purified by HPLC from the culture broth of Rhodococcus…
Novel isomarabarican triterpenes, exhibiting selective anti-proliferative activity against vascular endothelial cells, from marine sponge Rhabdastrella globostellata.
Structure-activity relationship and biological property of cortistatins, anti-angiogenic spongean steroidal alkaloids.
Specialized Transduction Designed for Precise High-Throughput Unmarked Deletions in Mycobacterium tuberculosis
The new methods for strain construction were demonstrated to generalize to all classes of genes and chromosomal loci by generating more than 100 targeted single- or multiple-deletion substitutions, paving the way for the generation of a complete ordered library of M. tuberculosis null strains.
Dysideamine, a new sesquiterpene aminoquinone, protects hippocampal neuronal cells against iodoacetic acid-induced cell death.
Two distinct steps for spontaneous generation of subprotoplasts from a disintegrated bryopsis cell.
The unusual nature of protoplasm to generate subprotoplasts spontaneously from disintegrated Bryopsis cells was examined. Protoplasm extruded from algal cells aggregated rapidly in cell sap which was…
New beauvericins, potentiators of antifungal miconazole activity, Produced by Beauveria sp. FKI-1366. I. Taxonomy, fermentation, isolation and biological properties.
- T. Fukuda, M. Arai, Y. Yamaguchi, R. Masuma, H. Tomoda, S. Ōmura
- BiologyThe Journal of antibiotics
- 25 February 2004
Three new beauvericins, designated beauversicins D, E and F, were isolated from the culture of Beauveria sp.