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Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors
TLDR
It is shown that adult mouse neural stem cells express higher endogenous levels of Sox2 and c- myc than embryonic stem cells, and that exogenous Oct4 together with either Klf4 or c-Myc is sufficient to generate iPS cells from Neural stem cells. Expand
Direct reprogramming of human neural stem cells by OCT4
TLDR
It is demonstrated that the transcription factor OCT4 is sufficient to reprogram human neural stem cells to pluripotency and will advance the field further towards understanding reprogramming and generating patient-specific pluripotent stem cells. Expand
Oct4-Induced Pluripotency in Adult Neural Stem Cells
TLDR
It is reported that exogenous expression of the germline-specific transcription factor Oct4 is sufficient to generate pluripotent stem cells from adult mouse NSCs and is demonstrated to be similar to embryonic stem cells in vitro and in vivo. Expand
Direct reprogramming of fibroblasts into neural stem cells by defined factors.
TLDR
It is shown that a combination of transcription factors induces mouse fibroblasts to directly acquire a neural stem cell identity-which is term as induced neural stem cells (iNSCs). Expand
Cell-to-cell expression variability followed by signal reinforcement progressively segregates early mouse lineages
TLDR
A model where stochastic cell-to-cell expression heterogeneity followed by signal reinforcement underlies ICM lineage segregation by antagonistically separating equivalent cells is proposed. Expand
Distinct Developmental Ground States of Epiblast Stem Cell Lines Determine Different Pluripotency Features
TLDR
The data suggest that different EpiSC lines may undergo self‐renewal into distinct developmental states, a finding with important implications for functional readouts such as reversion of Epi SCs to an mESC‐like state as well as directed differentiation. Expand
Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis
TLDR
It is shown that fatty acid synthase (Fasn), the key enzyme of de novo lipogenesis, is highly active in adult NSPC and that conditional deletion of Fasn in mouse NSPCs impairs adult neurogenesis. Expand
Initiation of trophectoderm lineage specification in mouse embryos is independent of Cdx2
TLDR
It is shown that effective elimination of both maternal and zygotic Cdx2 transcripts by an RNA interference approach resulted in failure of embryo hatching and implantation, but the developing blastocysts exhibited normal gross morphology, indicating that TE differentiation had been initiated. Expand
Human primordial germ cell commitment in vitro associates with a unique PRDM14 expression profile
TLDR
It is demonstrated that PGC commitment in humans shares key features with that of the mouse, but also highlights key differences, including transcriptional regulation during the early stage of human PGC development (3–6 weeks), which may lead to methodology for generating PSC‐derived gametes for reproductive medicine. Expand
Chromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming
TLDR
Using proteomics, components of the ATP-dependent BAF chromatin-remodeling complex are identified, which significantly increases reprogramming efficiency when used together with the four factors and represents an efficient method of generating reprogrammed cells. Expand
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