• Publications
  • Influence
Retinal degeneration in the rd mouse is caused by a defect in the β subunit of rod cGMP-phosphodiesterase
Evidence is presented that the candidate cDNA is the murine homologue of bovine phosphodiesterase β cDNA and that the mouse rd locus encodes the rod photoreceptor cGMP-phosphodiesterases β subunit.
Spectral tuning in the mammalian short-wavelength sensitive cone pigments.
A single amino acid substitution appears to be the dominant factor by which the majority of mammalian short-wavelength sensitive cone pigments have shifted their absorption maxima from the UV to the visible regions of the spectrum.
Notch1 functions to suppress cone-photoreceptor fate specification in the developing mouse retina
An unexpected role of Notch signaling in directly controlling neuronal cell-type composition is revealed, and a model by which, during normal retinogenesis, Notch1 functions to suppress cone-photoreceptor fate, allowing for the specification of the diversity of retinal cell types is suggested.
Isolation and characterization of cGMP phosphodiesterase from bovine rod outer segments.
A simple purification method has been developed for isolation of bovine cGMP phosphodiesterase from photoreceptor rod outer segments and, in the course of isolation, a second rod outer segment disc protein is purified.
Transient expression of thyroid hormone nuclear receptor TRβ2 sets S opsin patterning during cone photoreceptor genesis
Comparisons of spatiotemporal expression of TRβ2 and S opsin from embryonic day (E) 13 through adulthood in C57BL/6 retinae show that TR β2 is necessary for dorsal repression, but not ventral activation of S ops in adult animals.
Characterization of bovine rod outer segment G-protein.