M. Apostu

Publications46
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Citations85
Highly Influential Citations0
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Fast HPLC Method for the Determination of Piroxicam and its Application to Stability Study
A fast and robust RP-HPLC isocratic method was developed for determination of piroxicam in bulk materials and pharmaceutical formulations. Optimum separation of piroxicam and stress induced…
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A HPLC Method for the Determination of Bisoprolol in Tablets and its Application to a Bioequivalence Study
TLDR
This paper presents the results of a six-month study of the phytochemical fingerprinting technique, developed in Iasi during the period of May 21 to 29, 2013.
A New Liquid Chromatography-Tandem Mass Spectrometry Method for Determination of Bisoprolol in Human Plasma Samples
TLDR
A new liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the determination of bisoprolol in human plasma samples, using metoprool as internal standard and liquid-liquid extraction procedure.
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A New and Sensitive LC-MS/MS Method for the Determination of Clopidogrel in Human Plasma
TLDR
The proposed method has been validated for a linear range of 10-10000 mg/mL and the value of the regression coefficient was ≥0.99 and can be used for the therapeutic drug monitoring of clopidogrel.
[Membrane-selective electrode for atropine assay].
TLDR
This electrode was used with good results for quantitative assay by direct potentiometry and potentiometric titration of atropine sulphate from pharmaceutical formulations, and has a linear response in the concentration range of 10(-2)-10(-5) M atropin sulphate.
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Validation of a spectrophotometric assay method for bisoprolol using picric acid.
TLDR
The proposed and validated spectrophotometric method for the determination of bisoprolol is simple and cost effective.
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Spectrometric method for the assay of ramipril using molybdophosphoric acid.
TLDR
The proposed molecular absorbance spectrometric method for the assay of ramipril using molybdophosphoric acid in acidic medium is simple, easy to perform, linear, precise, accurate and robust.
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Ion-selective Membrane Electrodes for the Determination of Heavy Metals Construction characterization and applications
TLDR
This paper presents the results of a two-year study on the integration of EMMARM, a state-of-the-art machine that automates the very labor-intensive and therefore time-heavy and expensive and expensive process of analyzing EMTs.
Development of Dermal Films Containing Miconazole Nitrate
TLDR
The mechanical resistance and elongation tests demonstrated that the two films based on hydroxyethyl cellulose ( HEC) polymer were more elastic than the one prepared with hydroxypropyl methylcellulose (HPMC), which revealed that the HPMC film did not dry very well in the process of preparation by the evaporation of the solvent technique.
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[High blood and urine concentration of hepatotoxic mycotoxins (aflatoxin B1, sterigmatocystin) in patients with liver cirrhosis].
TLDR
Most of the patients presented detectable levels of mycotoxins, significantly increased in cases with liver cirrhosis, probable due to a specific metabolic pattern.
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