Amiodarone-induced block of sodium current in isolated cardiac cells.
- C. Follmer, M. Aomine, J. Yeh, D. Singer
- BiologyJournal of Pharmacology and Experimental…
- 1 October 1987
AMI blocks INa and shifts the availability curve in isolated myocytes, both of which contribute to the net tonic block and suggest that both rested state and inactivated state sodium channel block are factors in AMI's antiarrhythmic efficacy.
Effects of SG-75 (nicorandil) on electrical activity of canine cardiac Purkinje fibers: possible increase in potassium conductance.
- S. Imanishi, M. Arita, T. Kiyosue, M. Aomine
- BiologyJournal of Pharmacology and Experimental…
- 1 April 1983
It is concluded that SG-75 increases membrane K+ conductance in cardiac Purkinje fibers probably by modifying ix1 and iK1 channels without changing the slow inward currents and that the effects are not mediated by muscarinic receptors.
Diabetes mellitus decreases hippocampal release of neurotransmitters: an in vivo microdialysis study of awake, freely moving rats.
- T. Yamato, Y. Misumi, S. Yamasaki, M. Kino, M. Aomine
- Biology, PsychologyDiabetes, Nutrition and Metabolism. Clinical and…
- 1 June 2004
The data show that diabetes mellitus decreases in the monoamine release from the hippocampus in both experimentally and spontaneously diabetic rats.
Chronic diabetes mellitus prolongs action potential duration of rat ventricular muscles: circumstantial evidence for impaired Ca2+ channel.
It is suggested that altered Ca2+ current, but not altered Na(+)-Ca2+ exchange current or altered transient outward current, significantly prolongs action potential duration in diabetic rat ventricular muscles.
Suggestive evidence for inhibitory action of amiodarone on Na+, K+-pump activity in guinea pig heart.
- M. Aomine
- Biology, MedicineGeneral Pharmacology
- 1989
Nature of "residual fast channel" dependent action potentials and slow conduction in guinea pig ventricular muscle and its modification by isoproterenol.
- M. Arita, T. Kiyosue, M. Aomine, S. Imanishi
- Biology, ChemistryAmerican Journal of Cardiology
- 1 May 1983
Effects of amiodarone on barium-induced automatic activity in guinea pig ventricular muscle.
- M. Aomine
- Biology, ChemistryGeneral Pharmacology
- 1989
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