Cyclothiazomycin, a novel polythiazole-containing peptide with renin inhibitory activity. Taxonomy, fermentation, isolation and physico-chemical characterization.
- M. Aoki, T. Ohtsuka, H. Seto
- Chemistry, BiologyJournal of antibiotics (Tokyo. )
- 25 June 1991
Cyclothiazomycin is a novel renin inhibitor produced by Streptomyces sp. NR0516. It was isolated from fermentation broth by extraction with butyl alcohol, QAE-Toyopearl column chromatography and…
Panclicins, novel pancreatic lipase inhibitors. II. Structural elucidation.
- K. Yoshinari, M. Aoki, K. Yokose
- Chemistry, BiologyJournal of antibiotics (Tokyo. )
- 10 February 1994
Panclicins A-E are novel and potent pancreatic lipase inhibitors produced by Streptomyces sp. NR 0619. Their structures have been elucidated based on NMR and FAB-MS experiments. The relative…
Structural studies on avidinorubicin, a novel anthracycline with platelet aggregation inhibitory activity.
Avidinorubicin inhibited thrombin-induced platelet aggregation with an IC50 being 7.9 microM and was determined to be a novel anthracycline possessing two units of a new aminosugar, avidinosamine, in place of two decilonitrose groups in decilorubsicin.
Structure of cyclothiazomycin, a unique polythiazole-containing peptide with renin inhibitory activity. Part 1. Chemistry and partial structures of cyclothiazomycin
- M. Aoki, T. Ohtsuka, Y. Itezono, K. Yokose, K. Furihata, H. Seto
- Chemistry
- 7 January 1991
Structure of cyclothiazomycin, a unique polythiazole-containing peptide with renin inhibitory activity. Part 2. Total structure
- M. Aoki, T. Ohtsuka, Y. Itezono, K. Yokose, K. Furihata, H. Seto
- Chemistry
- 7 January 1991
BU-4794F, a new beta-1,3-glucan synthase inhibitor.
- M. Aoki, T. Andoh, T. Ueki, S. Masuyoshi, K. Sugawara, T. Oki
- ChemistryJournal of antibiotics (Tokyo. )
- 25 June 1993
New beta-1,3-glucan synthase inhibitor (BU-4794F) was isolated from the culture broth of Gilmaniella sp. FA4459. Structural studies indicated that it was a novel member of the papulacandin group of…
Structure of a novel phospholipase C inhibitor, vinaxanthone (Ro 09-1450), produced by penicillium vinaceum
- M. Aoki, Y. Itezono, H. Seto
- Chemistry
- 1991
Synthesis and antifungal activities of novel 1,3-beta-D-glucan synthase inhibitors. Part 1.
- K. Masubuchi, T. Okada, N. Shimma
- Biology, ChemistryBioorganic & Medicinal Chemistry Letters
- 21 May 2001
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