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Cyclic adenosine monophosphate–mediated protection against bile acid–induced apoptosis in cultured rat hepatocytes
Cyclic adenosine monophosphate (cAMP) has been shown to modulate apoptosis. To evaluate the role of cAMP in bile acid–induced hepatocyte apoptosis, we studied the effect of agents that increase cAMPExpand
Role of the PI3K/PKB signaling pathway in cAMP-mediated translocation of rat liver Ntcp.
  • C. Webster, M. Anwer
  • Biology, Medicine
  • American journal of physiology. Gastrointestinal…
  • 1 December 1999
cAMP stimulates Na+-taurocholate (TC) cotransport by translocating the Na+-TC-cotransporting peptide (Ntcp) to the plasma membrane. The present study was undertaken to determine whether theExpand
Activation of cAMP-guanine exchange factor confers PKA-independent protection from hepatocyte apoptosis.
cAMP has previously been shown to promote cell survival in a variety of cell types, but the downstream signaling pathway(s) of this antiapoptotic effect is unclear. Thus the role of cAMP signalingExpand
Cellular regulation of hepatic bile acid transport in health and cholestasis
Vectorial transport of solutes from the sinusoidal space to the canaliculus provides the osmotic driving force for bile formation and is accomplished by various transporters located at theExpand
PKCζ Is Required for Microtubule‐Based Motility of Vesicles Containing the ntcp Transporter
Intracellular trafficking regulates the abundance and therefore activity of transporters present at the plasma membrane. The transporter, Na+‐taurocholate co‐transporting polypeptide (ntcp), isExpand
Role of protein kinase C isoforms in bile formation and cholestasis
  • M. Anwer
  • Biology, Medicine
  • Hepatology
  • 1 September 2014
Transhepatic solute transport provides the osmotic driving force for canalicular bile formation. Choleretic and cholestatic agents affect bile formation, in part, by altering plasma membraneExpand
Taurolithocholate‐induced MRP2 retrieval involves MARCKS phosphorylation by protein kinase Cϵ in HUH‐NTCP Cells
Taurolithocholate (TLC) acutely inhibits the biliary excretion of multidrug‐resistant associated protein 2 (Mrp2) substrates by inducing Mrp2 retrieval from the canalicular membrane, whereas cyclicExpand
Role of intracellular calcium and protein kinases in the activation of hepatic Na+/taurocholate cotransport by cyclic AMP.
Glucagon and dibutyryl cyclic AMP (Bt2cAMP) stimulate Na+/taurocholate (TC) cotransport and increase the intracellular Ca2+ concentration ([Ca2+]i) of hepatocytes. Whether the effect of cAMP isExpand
Sodium-dependent bile salt transporters of the SLC10A transporter family: more than solute transporters
  • M. Anwer, B. Stieger
  • Biology, Medicine
  • Pflügers Archiv - European Journal of Physiology
  • 2013
The SLC10A transporter gene family consists of seven members and substrates transported by three members (SLC10A1, SLC10A2 and SLC10A6) are Na+-dependent. SLC10A1 (sodium taurocholate cotransportingExpand
Circulating microRNA, miR-122 and miR-221 signature in Egyptian patients with chronic hepatitis C related hepatocellular carcinoma.
AIM To explore the potential usefulness of serum miR-122 and miR-221 as non-invasive diagnostic markers of hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). METHODS This prospectiveExpand