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Prevention of the development of spontaneous hypertension in rats by captopril (SQ 14,225).
It is demonstrated that daily captopril therapy was able to completely prevent the development of spontaneous hypertension in male, weanling, spontaneously hypertensive rats. Expand
Angiotensin converting enzyme (ACE) inhibitors.
- M. Antonaccio
- Biology, Medicine
- Annual review of pharmacology and toxicology
Angiotensin converting enzyme inhibitors represent a new class of agents which were designed to retain only that unique property and results in the significant reduction of elevated blood pressure of various etiologies and in the amelioration of symptoms associated with congestive heart failure resistant to digitalis glycosides and diuretics. Expand
Captopril (SQ 14,225) (D-3-mercapto-2-methylpropranoyl-L-proline): a novel orally active inhibitor of angiotensin-converting enzyme and antihypertensive agent.
The results suggest that captopril acts in large part by inhibiting the renin-angiotensin-aldosterone system to reduce elevated blood pressure, especially in renindependent models of hypertension; the roles of the kallikrein-kinin-prostaglandin systems and sodium balance remain to be elucidated. Expand
Evidence for prejunctional inhibition of norepinephrine release by captopril in spontaneously hypertensive rats.
It is suggested that captopril causes a prejunctional inhibition of norepinephrine release to sympathetic nerve stimulation which is selective for the vasculature. Expand
Involvement of central GABA receptors in the regulation of blood pressure and heart rate of anesthetized cats.
An important role for GABA receptors in the central regulation of blood pressure and heart rate is suggested in anesthetized cats and the effects of both muscimol and GABA were reversed by either picrotoxin or bicuculline administered intravenously. Expand
Cardioprotection in ischemic rat hearts with the SH-containing angiotensin-converting enzyme inhibitor zofenopril: possible involvement of the ATP-sensitive potassium channel.
- C. Sargent, P. Sleph, +4 authors G. Grover
- The Journal of pharmacology and experimental…
- 1 May 1993
Results demonstrate for the first time a link between the cardioprotective effects of the SH-containing compounds zofenopril and n-acetyl cysteine and the KATP and the activity appears to be a receptor-mediated event which occurs in a manner different from classical KatP openers such as cromakalim. Expand
Inhibitors of angiotensin-converting enzyme.
Effects of chronic treatment with captopril (SQ 14,225), an orally active inhibitor of angiotensin I-converting enzyme, in spontaneously hypertensive rats.
Results indicate that chronic inhibition of ACE with captopril induces normalization of blood pressure in SHR, a normal-renin model of hypertension. Expand
Chronic antihypertensive effects of captopril (SQ 14,225), an orally active angiotensin I-converting enzyme inhibitor, in conscious 2-kidney renal hypertensive rats.
- B. Rubin, M. Antonaccio, +5 authors R. Laffan
- Chemistry, Medicine
- European journal of pharmacology
- 15 October 1978
It is indicated that chronic treatment with captopril decreased SBP and cardiac weights of RHR, and that HCTZ, or possibly other diuretics, can augment the antihypertensive effect ofcaptopril while having little or no effect by themselves. Expand
Reductions in blood pressure, heart rate and renal sympathetic nerve discharge in cats after the central administration of muscimol, a GABA agonist
It is concluded that central stimulation of GABA receptors by muscimol results in marked reductions in blood pressure, heart rate and RSND which are specifically antagonized by GABA receptor antagonists. Expand