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GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia.
Transient abnormal myelopoiesis (TAM), a preleukemic disorder unique to neonates with Down syndrome (DS), may transform to childhood acute myeloid leukemia (ML-DS). Acquired GATA1 mutations areExpand
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The CovS/CovR Acid Response Regulator Is Required for Intracellular Survival of Group B Streptococcus in Macrophages
ABSTRACT Group B Streptococcus (GBS) is a leading cause of neonatal meningitis and septicemia. The ability of this organism to survive inside phagocytic cells is poorly understood but thought to beExpand
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Incidence, etiology, and outcome of bacterial meningitis in infants aged <90 days in the United kingdom and Republic of Ireland: prospective, enhanced, national population-based surveillance.
BACKGROUND Bacterial meningitis remains a major cause of morbidity and mortality in young infants. Understanding the epidemiology and burden of disease is important. METHODS Prospective, enhanced,Expand
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Managing and preventing outbreaks of Gram-negative infections in UK neonatal units
De novo guidance on the management of Gram-negative bacteria outbreaks in UK neonatal units was developed in 2012 by a Department of Health, England Antimicrobial Resistance and Healthcare AssociatedExpand
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Clinical Characteristics and Risk Factors for Poor Outcome in Infants Less Than 90 Days of Age With Bacterial Meningitis in the United Kingdom and Ireland
Background: To describe the clinical characteristics and risk factors associated with poor outcome in infants <90 days of age with bacterial meningitis. Methods: Prospective, enhanced, nationalExpand
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Zinc nutrition of preschool children in the Denver Head Start program.
Low income diets provide relatively little zinc. This study was designed to evaluate the zinc nutritional states of 74 low income preschool children enrolled in the Denver Head Start Program. Zinc isExpand
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Characterization of lactate utilization and its implication on the physiology of Haemophilus influenzae
Haemophilus influenzae is a Gram-negative bacillus and a frequent commensal of the human nasopharynx. Earlier work demonstrated that in H. influenzae type b, l-lactate metabolism is associated withExpand
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Eighteen Months of “Matching Michigan” at a UK Neonatal Intensive Care Unit
Our “Matching Michigan” program has 3 focuses for identifying and reducing nosocomial infection. First, practical training to optimize infection control; second, root cause analysis of blood-cultureExpand
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Objectives: Bleeding from gastroesophageal varices is the most serious and life-threatening complication of cirrhosis and accounts for 10% of all cases of bleeding from the upper GI tract. It isExpand
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Assessment of healthcare delivery in the early management of bacterial meningitis in UK young infants: an observational study
Objective To define early presenting features of bacterial meningitis in young infants in England and to review the adequacy of individual case management as compared with relevant nationalExpand
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