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Allergen-induced eosinophil cytolysis is a primary mechanism for granule protein release in human upper airways.
The nature and extent of the ECL and its product indicate that allergen-induced cytolysis is a primary and major mechanism for the release of eosinophil proteins in human allergic airway inflammation in vivo.
Eosinophil degranulation status in allergic rhinitis: observations before and during seasonal allergen exposure
It is demonstrated that the nasal mucosa in allergic rhinitis features moderately degranulated eosinophils already at nonsymptomatic baseline conditions, and the tissue deposition of eosInophil granule proteins is dramatically elevated through increased eos inophil numbers, together with markedly augmented degranulation of individual cells.
Immediate effect of topical budesonide on allergen challenge-induced nasal mucosal fluid levels of granulocyte-macrophage colony-stimulating factor and interleukin-5.
It is demonstrated that GM-CSF and IL-5 are induced in a nonsymptomatic, late phase response to nasal allergen challenge, and that this cytokine response is prevented by single dose budesonide pretreatment.
Degranulation patterns of eosinophil granulocytes as determinants of eosinophil driven disease
Assessment of piecemeal degranulation would make it possible to delineate the conditions under which eosinophils are likely to contribute to disease processes, and this novel type of analysis may also guide and validate anti-eosinophile treatment options.
Incidence and remission of self‐reported allergic rhinitis symptoms in adults
The incidence and remission of allergic rhinitis in the general population in the same general population has been examined and it is concluded that vaccination is a viable treatment option for AR.
Allergen‐induced nasal hyperreactivity appears unrelated to the size of the nasal and dermal immediate allergic reaction
No correlation was found between the increased responsiveness and the size of initial immediate reaction either in the nose or in the skin, or the presence or size of any late phase dermal reaction, and further studies of the pathophysiology of this phenomenon are called for.
Cytolysis and piecemeal degranulation as distinct modes of activation of airway mucosal eosinophils.
Circulating eosinophil/basophil progenitors and nasal mucosal cytokines in seasonal allergic rhinitis
It is suggested that GM‐CSF may play a role in vivo to increase production of eosinophilic progenitors in allergic airway disease.
Effects of orally inhaled budesonide in seasonal allergic rhinitis.
It is suggested that nasal and systemic anti-eosinophil actions are produced at commonly employed dose levels of orally inhaled budesonide, which produces clinically significant anti-inflammatory effects in the entire airways, including the nasal mucosa, which is not exposed topically to the drug.