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The Immune Landscape of Cancer
SUMMARY We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified six… Expand
Functional microRNA involved in endometriosis.
Endometriosis is a common disease seen by gynecologists. Clinical features involve pelvic pain and unexplained infertility. Although endometriosis is pathologically characterized by endometrial… Expand
Molecular profiling uncovers a p53-associated role for microRNA-31 in inhibiting the proliferation of serous ovarian carcinomas and other cancers.
MicroRNAs (miRNA) regulate complex patterns of gene expression, and the relevance of altered miRNA expression to ovarian cancer remains to be elucidated. By comprehensively profiling expression of… Expand
Uterine smooth muscle tumor of uncertain malignant potential: a retrospective analysis.
- Saketh R. Guntupalli, P. Ramirez, M. Anderson, M. R. Milam, D. Bodurka, A. Malpica
- Gynecologic oncology
- 1 June 2009
OBJECTIVE This retrospective study was designed to evaluate the clinicopathologic features and outcomes of a cohort of patients diagnosed with uterine smooth muscle tumor of uncertain malignant… Expand
A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer.
- Ankur K Nagaraja, C. Creighton, +9 authors M. Matzuk
- Medicine, Biology
- Molecular endocrinology
- 1 February 2010
MicroRNAs (miRNAs) are small noncoding RNAs that direct gene regulation through translational repression and degradation of complementary mRNA. Although miRNAs have been implicated as oncogenes and… Expand
MiR-155 is a liposarcoma oncogene that targets casein kinase-1α and enhances β-catenin signaling.
Liposarcoma can be an aggressive, debilitating, and fatal malignancy. In this study, we identifed miRNAs associated with the differentiation status of liposarcoma to gain insight into the basis for… Expand
A role for BRCA1 in uterine leiomyosarcoma.
Uterine leiomyosarcoma (ULMS) is a rare gynecologic malignancy with a low survival rate. Currently, there is no effective treatment for ULMS. Infrequent occurrences of human ULMS hamper the… Expand
Uterine Leiomyosarcoma Management, Outcome, and Associated Molecular Biomarkers: A Single Institution’s Experience
- Kristelle Lusby, K. B. Savannah, +13 authors R. Pollock
- Annals of Surgical Oncology
- 20 January 2013
BackgroundUterine leiomyosarcoma (ULMS) is an aggressive, rapidly progressive tumor lacking clinical and molecular predictors of outcome.MethodsULMS patients (n = 349) were classified by disease… Expand
Adult Stature and Risk of Cancer at Different Anatomic Sites in a Cohort of Postmenopausal Women
- G. Kabat, M. Anderson, +8 authors T. Rohan
- Cancer Epidemiology, Biomarkers & Prevention
- 25 July 2013
Background: Prospective studies in Western and Asian populations suggest that height is a risk factor for various cancers. However, few studies have explored potential confounding or effect… Expand
Molecular pathway identification using biological network-regularized logistic models
- W. Zhang, Y. Wan, G. Allen, Kaifang Pang, M. Anderson, Zhandong Liu
- Medicine, Biology
- BMC Genomics
- 9 December 2013
BackgroundSelecting genes and pathways indicative of disease is a central problem in computational biology. This problem is especially challenging when parsing multi-dimensional genomic data. A… Expand