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The Immune Landscape of Cancer
SUMMARY We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified sixExpand
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Functional microRNA involved in endometriosis.
Endometriosis is a common disease seen by gynecologists. Clinical features involve pelvic pain and unexplained infertility. Although endometriosis is pathologically characterized by endometrialExpand
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Molecular profiling uncovers a p53-associated role for microRNA-31 in inhibiting the proliferation of serous ovarian carcinomas and other cancers.
MicroRNAs (miRNA) regulate complex patterns of gene expression, and the relevance of altered miRNA expression to ovarian cancer remains to be elucidated. By comprehensively profiling expression ofExpand
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Uterine smooth muscle tumor of uncertain malignant potential: a retrospective analysis.
OBJECTIVE This retrospective study was designed to evaluate the clinicopathologic features and outcomes of a cohort of patients diagnosed with uterine smooth muscle tumor of uncertain malignantExpand
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A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer.
MicroRNAs (miRNAs) are small noncoding RNAs that direct gene regulation through translational repression and degradation of complementary mRNA. Although miRNAs have been implicated as oncogenes andExpand
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MiR-155 is a liposarcoma oncogene that targets casein kinase-1α and enhances β-catenin signaling.
Liposarcoma can be an aggressive, debilitating, and fatal malignancy. In this study, we identifed miRNAs associated with the differentiation status of liposarcoma to gain insight into the basis forExpand
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A role for BRCA1 in uterine leiomyosarcoma.
Uterine leiomyosarcoma (ULMS) is a rare gynecologic malignancy with a low survival rate. Currently, there is no effective treatment for ULMS. Infrequent occurrences of human ULMS hamper theExpand
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Uterine Leiomyosarcoma Management, Outcome, and Associated Molecular Biomarkers: A Single Institution’s Experience
BackgroundUterine leiomyosarcoma (ULMS) is an aggressive, rapidly progressive tumor lacking clinical and molecular predictors of outcome.MethodsULMS patients (n = 349) were classified by diseaseExpand
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Adult Stature and Risk of Cancer at Different Anatomic Sites in a Cohort of Postmenopausal Women
Background: Prospective studies in Western and Asian populations suggest that height is a risk factor for various cancers. However, few studies have explored potential confounding or effectExpand
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Molecular pathway identification using biological network-regularized logistic models
BackgroundSelecting genes and pathways indicative of disease is a central problem in computational biology. This problem is especially challenging when parsing multi-dimensional genomic data. AExpand
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