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The Nordic countries as a cohort for pharmacoepidemiological research.
An overview of the prescription databases established in the Nordic countries is presented, as well as to elaborate on their unique potential for record linkage and cross-national comparison of drug utilization, to assist in resolving safety issues of international interest. Expand
Use of single and combined antithrombotic therapy and risk of serious upper gastrointestinal bleeding: population based case-control study
During the study period, exposure to combined antithrombotic regimens increased by 425% in the background population and is associated with high incidence of gastrointestinal bleeding. Expand
Adverse events with use of antiepileptic drugs: a prescription and event symmetry analysis
To assess adverse events with use of antiepileptic drugs (AEDs) by the method of sequence symmetry analysis.
Policies to Enhance Prescribing Efficiency in Europe: Findings and Future Implications
The 4E methodology allows European countries to concisely capture the range of current demand-side measures and plan for the future knowing that initiatives can be additive to further enhance their prescribing efficiency. Expand
Long term use of drugs affecting the renin-angiotensin system and the risk of cancer: a population-based case-control study.
The indication or possibly threshold for prescribing antihypertensives appears to be related to a small increase in cancer risk, and the ARB-cancer association is probably too weak to be addressed in observational studies, given their limitations. Expand
Drug utilization according to reason for prescribing: a pharmacoepidemiologic method based on an indication hierarchy
To develop a pharmacoepidemiologic method for drug utilization analysis according to indication, gender, and age by means of register‐based information. Statin utilization in 2005 was applied as anExpand
Selective Serotonin Reuptake Inhibitors and the Risk of Stroke: A Population-Based Case-Control Study
Current exposure to SSRIs is not associated with increased risk of intracerebral hemorrhage and is probably notassociated with a decreased risk of ischemic stroke. Expand
Risk of Stroke Associated With Nonsteroidal Anti-Inflammatory Drugs: A Nested Case-Control Study
Current exposure to NSAIDs is not a risk factor for intracerebral hemorrhage or subarachnoid hemorrhage, and NSAIDs probably offer no protection against first-ever ischemic stroke. Expand
Introduction to drug utilization research
The numerous applications of drug utilization research are illustrated in Part 3, which include sections on comparative drug utilizationResearch, drug utilization and health policy, and the assessment and improvement of the quality of medicine use. Expand
Factors influencing GPs’ choice between drugs in a therapeutic drug group. A qualitative study
How GPs choose between drugs in a therapeutic drug group is explored based on semi-structured ethnographic interviews to find that GPs balance both internal and external factors when choosing between analogues. Expand