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The Increased Activity of TRPV4 Channel in the Astrocytes of the Adult Rat Hippocampus after Cerebral Hypoxia/Ischemia
TLDR
It is shown that TRPV4 channels are involved in ischemia-induced calcium entry in reactive astrocytes and thus, might participate in the pathogenic mechanisms of astroglial reactivity following ischemic insult. Expand
Heterogeneity of Astrocytes: From Development to Injury – Single Cell Gene Expression
TLDR
To unravel astrocyte heterogeneity during postnatal development and after focal cerebral ischemia, single-cell gene expression profiling was employed in acutely isolated cortical GFAP/EGFP-positive cells to gain insight into the role of glial markers and ion channels/transporters/receptors in maintaining K+ and glutamate homeostasis per cell. Expand
Quantification of astrocyte volume changes during ischemia in situ reveals two populations of astrocytes in the cortex of GFAP/EGFP mice
TLDR
It is concluded that two distinct populations of astrocytes are present in the cortex of GFAP/EGFP mice, based on volume and Vm changes during exposure to OGD or OGDpH 6.8. Expand
Cell Death/Proliferation and Alterations in Glial Morphology Contribute to Changes in Diffusivity in the Rat Hippocampus after Hypoxia—Ischemia
TLDR
The ADCW increase in the CA1 region underlain by altered cellular composition and glial morphology suggests that considerable changes in extracellular signal transmission might occur in the late phases of reperfusion after H/I. Expand
Distinct Expression/Function of Potassium and Chloride Channels Contributes to the Diverse Volume Regulation in Cortical Astrocytes of GFAP/EGFP Mice
TLDR
It is proposed that the diverse volume changes displayed by cortical astrocytes during OGD mainly result from their distinct expression patterns of ClC2 and K2P channels. Expand
Increased expression of hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels in reactive astrocytes following ischemia
TLDR
The expression of Hcn1–4 genes encoding hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels in reactive astrocytes following focal cerebral ischemia or global cerebral isChemia is demonstrated and could be an important therapeutic target in poststroke therapy. Expand
Altered Astrocytic Swelling in the Cortex of α-Syntrophin-Negative GFAP/EGFP Mice
TLDR
The deletion of α-syntrophin markedly alters astrocyte swelling during severe hypoosmotic stress, OGD or high K+. Expand
Glial Cells - The Key Elements of Alzheimer´s Disease.
TLDR
This review summarizes recent findings regarding the role/participation of glial cells in pathogenesis of AD, focusing on changes in their morphology, functions, proteins and gene expression profiles and considers the participation of oligodendrocytes in the pathogenesis and progression of AD. Expand
NMDA Receptors in Glial Cells: Pending Questions
TLDR
This review provides an overview of glial NMDA receptors with respect to ischemic brain injury and focuses on the NMDA receptor subunits present in the particular glial cell types, which give them special characteristics different from those of neurons. Expand
RT-qPCR work-flow for single-cell data analysis.
TLDR
This workflow is provide guide to the rapidly growing community studying single-cells by means of reverse transcription quantitative real-time PCR profiling and demonstrates different strategies for handling missing data and scaling data for downstream multivariate analysis. Expand
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