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Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)*
  • M. Amano, Masaaki Ito, +5 authors K. Kaibuchi
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 23 August 1996
TLDR
The phosphorylation of MLC by Rho-kinase resulted in the facilitation of the actin activation of myosin ATPase, which may partly account for the mechanism by which Rho regulates cytokinesis, cell motility, or smooth muscle contraction. Expand
Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)
TLDR
Rho appears to inhibit myosin phosphatase through the action of Rho-kinase, which is activated by GTP·RhoA, phosphorylation of MBS and MLC in NIH 3T3 cells. Expand
Rho-Kinase Phosphorylates COOH-terminal Threonines of Ezrin/Radixin/Moesin (ERM) Proteins and Regulates Their Head-to-Tail Association
TLDR
Observations indicate that the Rho-kinase–dependent phosphorylation interferes with the intramolecular and/ or intermolecular head-to-tail association of ERM proteins, which is an important mechanism of regulation of their activity as actin filament/plasma membrane cross-linkers. Expand
Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase
TLDR
Rho-kinase appears to mediate signals from Rho and to induce the formation of stress fibers and focal adhesions. Expand
Rho‐associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.
TLDR
P purified a Rho‐interacting protein with a molecular mass of approximately 164 kDa (p164) from bovine brain that bound to GTPgammaS (a non‐hydrolyzable GTP analog) and is likely to be a putative target serine/threonine kinase for Rho and serves as a mediator of the RHo‐dependent signaling pathway. Expand
Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells.
TLDR
The role of the Rho-Rho-kinase pathway in contractile processes of smooth muscle and in non-muscle cell functions, and the pathophysiological implications of this pathway are summarized. Expand
Regulation and functions of Rho-associated kinase.
TLDR
This review focuses on the regulation and cellular functions of Rho-associated kinase, which appears to mediate a large proportion of the signals from Rho and regulate dynamic reorganization of cytoskeletal proteins, such as stress fiber and focal adhesion formation. Expand
Phosphorylation of Myosin-Binding Subunit (Mbs) of Myosin Phosphatase by Rho-Kinase in Vivo
TLDR
Results indicate that MBS is phosphorylated by Rho-kinase downstream of Rho in vivo, and suggest that myosin phosphatase and Rho -kinase spatiotemporally regulate the phosphorylation state of RHo-kinases substrates including MLC and ERM family proteins in vivo in a cooperative manner. Expand
Rho-Kinase/ROCK: A Key Regulator of the Cytoskeleton and Cell Polarity
TLDR
This review focuses on the structure, function, and modes of activation and action of Rho‐kinase, which is involved in a wide range of diseases such as vasospasm, pulmonary hypertension, nerve injury, and glaucoma. Expand
Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells.
Members of the Rho family of small Ras-like GTPases--including RhoA, -B, and -C, Rac1 and -2, and Cdc42--exhibit guanine nucleotide-binding activity and function as molecular switches, cyclingExpand
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