Tumor cell escape from therapy‐induced senescence
Protective effect of rutin supplementation against cisplatin-induced Nephrotoxicity in rats
It is suggested that the anti-oxidant and anti-inflammatory effect of rutin may prevent CP-induced nephrotoxicity via decreasing the oxidative stress, inhibiting the interconnected ROS/JNK/TNF/P38 MAPK signaling pathways, and repairing the histopathological changes against cisplatin administration.
Clearance of therapy‐induced senescent tumor cells by the senolytic ABT‐263 via interference with BCL‐XL–BAX interaction
It is shown that sensitivity of these senescent tumor cells to the senolytic ABT‐263 (navitoclax) is provided, therefore providing a “two‐hit” approach to eliminate senescent tumors that persist after exposure to chemotherapy or radiation.
Cytotoxic Autophagy in Cancer Therapy
- K. Sharma, N. Le, M. Alotaibi, D. Gewirtz
- Biology, MedicineInternational Journal of Molecular Sciences
- 1 June 2014
This review will describe autophagic cell death induced in breast tumor cells, lung cancer cells as well as glioblastoma, demonstrating that it cannot be concluded that stress induced autophagy is, of necessity, cytoprotective in function.
Short chain fatty acid, acetate ameliorates sepsis‐induced acute kidney injury by inhibition of NADPH oxidase signaling in T cells
Therapeutic treatment with Ibrutinib attenuates imiquimod-induced psoriasis-like inflammation in mice through downregulation of oxidative and inflammatory mediators in neutrophils and dendritic cells.
Differential Radiation Sensitivity in p53 Wild-Type and p53-Deficient Tumor Cells Associated with Senescence but not Apoptosis or (Nonprotective) Autophagy
Findings indicate that senescence, rather than apoptosis, plays a central role in determination of radiosensitivity; furthermore, autophagy is likely to have minimal influence on radiosensitivity under conditions where autophagic takes the nonprotective form.
Dysregulation of T cell immunoglobulin and mucin domain 3 (TIM-3) signaling in peripheral immune cells is associated with immune dysfunction in autistic children.
Characterization of Apoptosis in a Breast Cancer Cell Line after IL-10 Silencing
- M. Alotaibi, Z. Hassan, O. Al‐Shabanah
- Biology, MedicineAsian Pacific Journal of Cancer Prevention
- 1 March 2018
The production of IL-10 may represent a new escape mechanism by breast cancer cells to evade destruction by the immune system and might represent a promising new target for therapeutic strategies.
Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent Cells
- M. Alotaibi, K. Sharma, T. Saleh, L. Povirk, E. Hendrickson, D. Gewirtz
- BiologyRadiation Research
- 2 March 2016
Inhibition of DNA repair via PARP inhibition may initially sensitize tumor cells to radiation via the promotion of senescence, but this strategy does not appear to interfere with proliferative recovery, which could ultimately contribute to disease recurrence.