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Nitric oxide-20-hydroxyeicosatetraenoic acid interaction in the regulation of K+ channel activity and vascular tone in renal arterioles.
Results indicate that inhibition of the formation of 20-HETE contributes to the activation of K+ channels and the vasodilator effects of NO in the renal microcirculation.
Hypertension in obese Zucker rats. Role of angiotensin II and adrenergic activity.
The results suggest that increased arterial pressure in obese Zucker rats depends in part on angiotensin II, however, additional mechanisms may also contribute to increased blood pressure in obesity Zucker rats.
Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II.
It is suggested that acute and chronic elevations in circulating ANG II levels increase the formation of 20- HETE in the kidney and peripheral vasculature and that 20-HETE contributes to the acute and Chronic pressor effects of ANG II.
Renal And Cardiovascular Actions Of 20‐Hydroxyeicosatetraenoic Acid And Epoxyeicosatrienoic Acids
1. Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP)‐dependent pathways to epoxyeicosatrienoic acids (EET) and 20‐hydroxyeicosatetraenoic acid (20‐HETE) in the kidney and the peripheral
Inhibition of 20-HETE production contributes to the vascular responses to nitric oxide.
Results indicate that NO inhibits cytochrome P4504A enzymes and that inhibition of the production of 20-HETE contributes to the vasodilatory effects of NO.
20-HETE agonists and antagonists in the renal circulation.
Findings suggest that 20-HETE agonists and antagonists require a carboxyl or an ionizable group on carbon 1 and a double bond near the 14 or 15 carbon, whereas antagonists lack this reactive group.
Localization of cytochrome P-450 4A isoforms along the rat nephron.
The results indicate that the expression of P- 450 4A isoforms in the kidney of rats is sex dependent and that different P-450 4Aisoforms are expressed throughout various nephron segments and the renal vasculature of rats.
P-450 Eicosanoids: A Novel Signaling Pathway Regulating Renal Function.
Cytochrome P-450 enzymes primarily metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) and 20-HETE in the kidney to serve as second messengers that play a central role in the regulation of renal vascular tone and sodium reabsorption in the proximal tubule and thick ascending loop of Henle.
Effects of lipid-lowering agents in the Dahl salt-sensitive rat.
It is indicated that fenofibrate prevented the development of hypertension and reduced subsequent glomerular injury in Dahl S rats, probably secondary to increased renal production of 20-HETE.
Contribution of 20-HETE to vasodilator actions of nitric oxide in the cerebral microcirculation.
It is suggested that NO dilates cerebral arteries through both cGMP-dependent and cG MP-independent pathways and that inhibition of 20-HETE formation contributes to the cerebral vasodilator response to NO both in vitro and in vivo.