Giant virus with a remarkable complement of genes infects marine zooplankton
- M. Fischer, M. Allen, W. H. Wilson, C. Suttle
- BiologyProceedings of the National Academy of Sciences
- 25 October 2010
Phylogenetic analysis indicates that CroV is a nucleocytoplasmic large DNA virus, with Acanthamoeba polyphaga mimivirus as its closest relative, although less than one-third of the genes of CroV have homologs in Mimivirus.
Complete Genome Sequence and Lytic Phase Transcription Profile of a Coccolithovirus
- W. H. Wilson, D. Schroeder, P. Ghazal
- BiologyScience
- 12 August 2005
The genus Coccolithovirus is a recently discovered group of viruses that infect the globally important marine calcifying microalga Emiliania huxleyi and contains six RNA polymerase subunits and a novel promoter, suggesting this virus encodes its own transcription machinery.
The minimum information about a genome sequence (MIGS) specification
- D. Field, G. Garrity, A. Wipat
- BiologyNature Biotechnology
- 1 May 2008
Here, the minimum information about a genome sequence (MIGS) specification is introduced with the intent of promoting participation in its development and discussing the resources that will be required to develop improved mechanisms of metadata capture and exchange.
The “Cheshire Cat” escape strategy of the coccolithophore Emiliania huxleyi in response to viral infection
- M. Frada, I. Probert, M. Allen, W. H. Wilson, C. de Vargas
- BiologyProceedings of the National Academy of Sciences
- 14 October 2008
Resistance of the haploid phase of E. huxleyi provides an escape mechanism that involves separation of meiosis from sexual fusion in time, thus ensuring that genes of dominant diploid clones are passed on to the next generation in a virus-free environment.
The Phycodnaviridae: the story of how tiny giants rule the world.
- W. H. Wilson, J. V. Van Etten, M. Allen
- BiologyCurrent Topics in Microbiology and Immunology
- 2009
The genome analyses have revealed more than 1000 unique genes, with only 14 homologous genes in common among the three genera of phycodnaviruses sequenced to date, indicating that their gene diversity far exceeds the number of so-called core genes.
Host-virus shift of the sphingolipid pathway along an Emiliania huxleyi bloom: survival of the fattest.
- A. Pagarete, M. Allen, W. H. Wilson, Susan A. Kimmance, C. de Vargas
- BiologyEnvironmental Microbiology
- 1 November 2009
A unique insight is provided into the transcriptional interplay of homologous metabolic pathways between virus and host during temporal progression of oceanic E. huxleyi blooms, which fit the hypothesis according to which viral sphingolipids are involved in the timing and physical processes of virion release from the host cells.
Horizontal gene transfer of an entire metabolic pathway between a eukaryotic alga and its DNA virus.
- A. Monier, A. Pagarete, H. Ogata
- Biology, Environmental ScienceGenome Research
- 18 May 2009
P phylogenetic evidence is reported for the transfer of seven genes involved in the sphingolipid biosynthesis pathway between the cosmopolitan eukaryotic microalga Emiliania huxleyi and its large DNA virus EhV, the first clear case of horizontal gene transfer of multiple functionally linked enzymes in a eukARYotic phytoplankton-virus system.
The response of Escherichia coli to exposure to the biocide polyhexamethylene biguanide.
- M. Allen, G. F. White, A. Morby
- BiologyMicrobiology
- 1 April 2006
The results showed that a wide range of genes was altered in transcriptional activity and that all of the corresponding knockout strains subsequently challenged with biocide were altered in tolerance, suggesting a novel dimension in the mechanism of action of PHMB based on its interaction with nucleic acids.
Evolutionary history of the Coccolithoviridae.
- M. Allen, D. Schroeder, M. Holden, W. H. Wilson
- BiologyMolecular biology and evolution
- 2006
The presence of six RNA polymerase subunits (unique among the Phycodnaviridae) suggests both a unique evolutionary history and a unique lifestyle for this intriguing virus.
From small hosts come big viruses: the complete genome of a second Ostreococcus tauri virus, OtV-1.
- K. Weynberg, M. Allen, K. Ashelford, D. Scanlan, W. H. Wilson
- BiologyEnvironmental Microbiology
- 1 November 2009
Fifteen core genes common to nuclear-cytoplasmic large dsDNA virus (NCLDV) genomes were identified in the OtV-1 genome and new sequence data may help to redefine the classification of the core genes of these viruses and shed new light on their evolutionary history.
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