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Ascorbic Acid Reduces the Adverse Effects of Delayed Administration of Tissue Plasminogen Activator in a Rat Stroke Model
Delayed treatment of stroke with recombinant tissue plasminogen activator (r‐tPA) induces overexpression of matrix metalloproteinase 9 (MMP‐9) which leads to breakdown of the blood–brain barrierExpand
Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats
The findings of the present study suggest that part of the neuroprotective effects of sigma-1 receptor agonists may be mediated through a dual effect on cytokine release following stroke. Expand
The effect of Wi-Fi electromagnetic waves in unimodal and multimodal object recognition tasks in male rats
Results of this study showed that chronic exposure to Wi-Fi electromagnetic waves might impair both unimodal and cross-modal encoding of information. Expand
The effect of the anti-diabetic drug metformin on behavioral manifestations associated with ovariectomy in mice
It is demonstrated that ovariectomy caused cognitive impairments and anxiety, as well as decreased BDNF levels, and administration of metformin improves ovariectomized mice-related disorders such as cognitive impairment and anxiety. Expand
Neuroprotective Consequences of Postconditioning on Embolic Model of Cerebral Ischemia in Rat
Ischemic postconditioning reduces infarct volume and brain edema, decreases hyperemia following to injury and improves neurological functions after the embolic model of stroke. Expand
The Possible Role of Toll-Like Receptor 4 in the Pathology of Stroke.
It is proved that animals with TLR4 deficiency have higher protection against ischemia and that the absence ofTLR4 reduces neuroinflammation and injuries associated with brain trauma, and that TLR 4 deficiency may play a neuroprotective role in the occurrence of stroke. Expand
Effect of Hydro-Alcoholic Extract of Teucrium Polium on Castor Oil-Induced Diarrhea in Male Rat
Based on the data, essential oil of TP has an effect similar to diphenoxylate on the reduction of osmotic diarrhea symptoms and also reduces the volume of excreted water. Expand
Vitex Agnus Castus Extract Improves Learning and Memory and Increases the Transcription of Estrogen Receptor α in Hippocampus of Ovariectomized Rats
Based on the data, VAC extract improves learning and memory in ovariectomized rats and is possibly associated with an increase in ERα gene expression in the hippocampal formation. Expand
Delayed post ischemic treatment with Rosiglitazone attenuates infarct volume, neurological deficits and neutrophilia after embolic stroke in rat
Treatment with RGZ, starting 24 h after stroke, can reduce ischemic injury, improve neurological outcome, and prevent neutrophilia, and may support the idea that RGZ has an extended therapeutic window for the treatment of isChemic stroke, as it targets delayed pathways. Expand
Treatment with troxerutin protects against cisplatin-induced kidney injury in mice
It is demonstrated that Tro has protective effects against CP-induced nephrotoxicity through improving the biochemical indices and the oxidative stress parameters. Expand