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Generation of superoxide radicals by copper-glutathione complexes: redox-consequences associated with their interaction with reduced glutathione.
The superoxide-generating capacity of the Cu(I)-[GSH](2) complex is investigated, the occurrence and chemical nature of the oxidized complex which is formed upon removing of superoxide radicals from the former reaction are demonstrated, and some of the redox consequences associated with the interaction are addressed. Expand
Inhibition of mitochondrial complex I by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action.
The exposed findings reveal that complex I inhibition is a common deleterious effect of NSAIDs at the mitochondrial level, and that such effect is, for all tested agents, susceptible to be prevented by quercetin. Expand
Redox-implications associated with the formation of complexes between copper ions and reduced or oxidized glutathione.
The most relevant chemical and biological evidence on the formation of the Cu(I)-[GSH]2 and Cu(II)-GSSG complexes and on the potential redox implications associated with their intracellular occurrence are reviewed. Expand
Superoxide-dependent reduction of free Fe(3+) and release of Fe(2+) from ferritin by the physiologically-occurring Cu(I)-glutathione complex.
The ability of the Cu(I)-[GSH](2) complex to generate the redox-active Fe(2+) species is demonstrated and it is suggested that by favouring the occurrence of superoxide-driven Fenton reactions, its pro-oxidant potential could be increased beyond its initial O2·--generating capacity. Expand
Redox-changes associated with the glutathione-dependent ability of the Cu(II)-GSSG complex to generate superoxide.
The interaction between GSH and Cu(II)-GSSG could be seen as a potential mechanism to regenerate continuously the Cu(I)-[GSH](2) complex and thereby affect the ability of the latter to generate superoxide. Expand
Substituent effects on reactivity of 3-cinnamoylcoumarins with thiols of biological interest
The Michael addition reactions of the biothiols cysteine, homocysteine, cysteinyl-glycine, γ-glutamyl-cysteine and glutathione with 3-cinnamoylcoumarin derivatives (ChC1–ChC4) in aqueous solution (30Expand
Coumarin-Based Fluorescent Probes for Dual Recognition of Copper(II) and Iron(III) Ions and Their Application in Bio-Imaging
Two new coumarin-based “turn-off” fluorescent probes are synthesized and their detection of copper(II) and iron(III) ions was studied, showing that both compounds are highly selective for Cu2+ and Fe3+ ions over other metal ions. Expand
Double edge redox-implications for the interaction between endogenous thiols and copper ions: In vitro studies.
The data indicate that, depending on their molar ratio, the interaction between Cu(2+) and the tested thiols would give place to mixtures containing either: (i) time-stable and ascorbate-reducible Cu(II)-complexes which display free radical-scavenging properties, or (ii)Time-stable but redox-inactive towards oxygen Cu(I)- complexes. Expand
The development of a fluorescence turn-on sensor for cysteine, glutathione and other biothiols. A kinetic study
Two fluorescence probes for the detection of cysteine (Cys), glutathione (GSH) and other biothiols, such as homocysteine (Hcy) and cysteinyl-glycine (Cys-Gly), were developed. These molecular probesExpand
Experimental and theoretical studies on the nucleofugality patterns in the aminolysis and phenolysis of S-aryl O-aryl thiocarbonates.
The reactions of S-phenyl, S-(4-chlorophenyl), and S-(2,3,4,5,6-pentafluorophenyl) 4-nitrophenyl thiocarbonates (9, 11, and 16, respectively) with a series of secondary alicyclic (SA) amines are subjected to a kinetic investigation and a theoretical analysis based on the group electrophilicity index is completed. Expand