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Some effects of jet-lag and their alleviation by melatonin
Melatonin significantly improved ‘jet lag’ in healthy volunteers flown from London to San Francisco between 20 November 1985 and 25 January 1986 and remained there for 14 days prior to flight home.
Suppression of nocturnal plasma melatonin and 6-sulphatoxymelatonin by bright and dim light in man.
- C. Bojkowski, M. Aldhous, J. Arendt
- BiologyHormone and metabolic research = Hormon- und…
- 1 September 1987
Dim (300 lux) and bright (2500 lux) light, both significantly suppressed melatonin levels compared to less than 1 lux at the following time points 0100 h, 0115 h and 0130 h, and one subject did not show suppression with 300 lux.
Alleviation of jet lag by melatonin: preliminary results of controlled double blind trial.
Melatonin, a methoxyindole secreted by the pineal gland, might be simpler and more effective in treating jet lag and its ability to transduce light-dark information, its hypnotic effects in man, and its low toxicity were examined.
THE EFFECTS OF EXOGENOUS MELATONIN ON ENDOCRINE FUNCTION IN MAN
- J. Wright, M. Aldhous, C. Franey, J. English, J. Arendt
- Biology, MedicineClinical endocrinology
- 1 April 1986
The observations suggest that the potential therapeutic use of melatonin as a hypnotic or in the treatment of jet lag is unlikely to be complicated by undesirable endocrine effects, and that overall PRL levels were higher in spring than in autumn.
Radioimmunoassay for 6-Sulphatoxymelatonin in Urine Using an Iodinated Tracer
Comparisons with the RIA using 3H-aMT6s label gave good correlation, as did comparison with a gas chromatography mass spectroscopy for total free and conjugated 6-hydroxymelatonin.
Plasma concentrations of melatonin in man following oral absorption of different preparations.
- M. Aldhous, C. Franey, J. Wright, J. Arendt
- BiologyBritish journal of clinical pharmacology
- 1 April 1985
The plasma concentrations of melatonin in man, fasting and fed, were determined after ingestion of three different oral preparations and these preparations should be of use in the study of timed melatonin administration in man.
SYNCHRONISATION OF A DISTURBED SLEEP-WAKE CYCLE IN A BLIND MAN BY MELATONIN TREATMENT
Morning or night-time melatonin is ineffective in seasonal affective disorder.
Acute treatment with desipramine stimulates melatonin and 6-sulphatoxy melatonin production in man.
- C. Franey, M. Aldhous, S. Burton, S. Checkley, J. Arendt
- Biology, MedicineBritish journal of clinical pharmacology
- 1 July 1986
Acute administration of the antidepressant drug desipramine in man, increased evening melatonin secretion, which reached peak plasma levels 2-4 h earlier than after placebo administration, and it was shown that this stimulation was not an effect of DMI inhibition on the hepatic metabolism of melatonin to 6-sulphatoxy melatonin (aMT6s).
Comparative pharmacokinetics of doxorubicin given by three different schedules with equal dose intensity in patients with breast cancer
- C. Twelves, N. Dobbs, M. Aldhous, P. Harper, R. Rubens, M. Richards
- Medicine, BiologyCancer Chemotherapy and Pharmacology
It is concluded that drug scheduling has significant effects on doxorubicin pharmacokinetics, as indicated by area under the concentration-time curve, than weekly or 3-weekly bolus treatment.