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Mutational screening of RET, HRAS, KRAS, NRAS, BRAF, AKT1, and CTNNB1 in medullary thyroid carcinoma.
TLDR
This study supports the clinical relevance of screening MTC patients for RET mutations and indicates that mutations in BRAF, AKT1, and CTNNB1 are likely not to play a role in MTC. Expand
KIF2A regulates the development of dentate granule cells and postnatal hippocampal wiring
TLDR
It is suggested that postnatal KIF2A is a key length regulator of DGC developing neurites and is involved in the establishment of precise postnatal hippocampal wiring. Expand
The role of epigenetics in personalized medicine: challenges and opportunities
TLDR
To realize the promise of personalized medicine, both genetic and epigenetic diagnostic testing will be required, and the advances that have been made as well as the challenges for the future are discussed. Expand
Proangiogenic Effect of Metformin in Endothelial Cells Is via Upregulation of VEGFR1/2 and Their Signaling under Hyperglycemia-Hypoxia
TLDR
Metformin’s dual effect in hyperglycemia-chemical hypoxia is mediated by direct effect on VEGFR1/R2 leading to activation of cell migration through MMP16 and ROCK1 upregulation, and inhibition of apoptosis by increase in phospho-ERK1/2 and FABP4, components of VEGF signaling cascades. Expand
The role of viruses in neurodegenerative and neurobehavioral diseases.
TLDR
The main focus of this review is to illustrate the association between viral infections and both neurodegenerative and neurobehavioral diseases, so that the possible mechanism and pathway of neuro degenerative diseases can be better explained. Expand
Establishing genomic/transcriptomic links between Alzheimer's disease and type 2 diabetes mellitus by meta-analysis approach.
TLDR
The findings implicate diabetic disorders in the pathogenesis of AD, and provide a basis for future candidate studies based on specific pathways, to understand the molecular link between T2DM and AD. Expand
RASSF1A methylation is predictive of poor prognosis in female breast cancer in a background of overall low methylation frequency.
TLDR
Although there was no significant correlations between any methylation event and disease-specific survival, methylation of MYOD1 or RASSF1A was associated with lower disease-free survival and increased chance of disease recurrence, and multivariate (Cox) regression analysis identified RASSf1A as an independent predictor of poor prognosis in terms of disease- free survival in this cohort. Expand
An association of virus infection with type 2 diabetes and Alzheimer's disease.
TLDR
The association of few common viruses like Hepatitis C Virus and Herpes Simplex Virus-1 which affects both diabetes and AD and the pathological links of Influenza virus, Cytomegalovirus, West Nile virus, Enterovirus and Borna disease virus in AD are discussed. Expand
High expression of matrix metalloproteinases: MMP-2 and MMP-9 predicts poor survival outcome in colorectal carcinoma.
TLDR
MMPs expression patterns provide useful prognostic information in CRC, while predicting the patients at high risk for recurrent disease, while determining the prognostic potential of matrix metalloproteinases. Expand
Frequency of Mediterranean mutation among a group of Saudi G6PD patients in Western region‐Jeddah
TLDR
The frequency of exons 6 mutations responsible for G6PD deficiency (Mediterranean type) is reported for the first time from this region, with a figure of 50.1% and points to the low genetic diversity in the studied population. Expand
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