Anti-cancer effects of Ajwa dates (Phoenix dactylifera L.) in diethylnitrosamine induced hepatocellular carcinoma in Wistar rats
- Fazal Khan, T. Khan, M. Al-Qahtani
- Biology, MedicineBMC Complementary and Alternative Medicine
- 22 August 2017
Restoration of anti-oxidant enzymes, liver enzymes, cytokines balance and gene expression to normal levels following ADE treatment indicates that ADE improves liver function and inhibits HCC, and ADE can be used together with conventional therapeutics for HCC.
Mutational screening of RET, HRAS, KRAS, NRAS, BRAF, AKT1, and CTNNB1 in medullary thyroid carcinoma.
- H. Schulten, J. Al-Maghrabi, M. Al-Qahtani
- Biology, MedicineAnticancer Research
- 1 December 2011
This study supports the clinical relevance of screening MTC patients for RET mutations and indicates that mutations in BRAF, AKT1, and CTNNB1 are likely not to play a role in MTC.
Individualized medicine enabled by genomics in Saudi Arabia
- M. Abu-Elmagd, M. Assidi, M. Al-Qahtani
- BiologyBMC Medical Genomics
- 15 January 2015
It is concluded that CEGMR will continue to play a pivotal role in advances in the field of genomics and research in this area is facing a number of challenges including generating high quality control data from Saudi population and policies for using these data need to comply with the international set up.
KIF2A regulates the development of dentate granule cells and postnatal hippocampal wiring
- Noriko Homma, Ruyun Zhou, M. I. Naseer, A. Chaudhary, M. Al-Qahtani, N. Hirokawa
- BiologyeLife
- 9 January 2018
It is suggested that postnatal KIF2A is a key length regulator of DGC developing neurites and is involved in the establishment of precise postnatal hippocampal wiring.
The role of epigenetics in personalized medicine: challenges and opportunities
To realize the promise of personalized medicine, both genetic and epigenetic diagnostic testing will be required, and the advances that have been made as well as the challenges for the future are discussed.
Proangiogenic Effect of Metformin in Endothelial Cells Is via Upregulation of VEGFR1/2 and Their Signaling under Hyperglycemia-Hypoxia
- S. Bakhashab, F. Ahmed, J. Weaver
- Biology, MedicineInternational Journal of Molecular Sciences
- 1 January 2018
Metformin’s dual effect in hyperglycemia-chemical hypoxia is mediated by direct effect on VEGFR1/R2 leading to activation of cell migration through MMP16 and ROCK1 upregulation, and inhibition of apoptosis by increase in phospho-ERK1/2 and FABP4, components of VEGF signaling cascades.
RASSF1A methylation is predictive of poor prognosis in female breast cancer in a background of overall low methylation frequency.
- A. Buhmeida, A. Merdad, A. Dallol
- BiologyAnticancer Research
- 1 September 2011
Although there was no significant correlations between any methylation event and disease-specific survival, methylation of MYOD1 or RASSF1A was associated with lower disease-free survival and increased chance of disease recurrence, and multivariate (Cox) regression analysis identified RASSf1A as an independent predictor of poor prognosis in terms of disease- free survival in this cohort.
The role of viruses in neurodegenerative and neurobehavioral diseases.
- Sajjad Karim, Z. Mirza, S. S. Sohrab
- Biology, PsychologyCNS and Neurological Disorders - Drug Targets
- 31 August 2014
The main focus of this review is to illustrate the association between viral infections and both neurodegenerative and neurobehavioral diseases, so that the possible mechanism and pathway of neuro degenerative diseases can be better explained.
MicroRNAs as potential drug targets for therapeutic intervention in colorectal cancer
- M. Jafri, S. K. Zaidi, S. Ansari, M. Al-Qahtani, J. Shay
- Biology, MedicineExpert opinion on therapeutic targets
- 18 July 2015
Targeting miRNAs provides an emerging opportunity to develop effective miRNA-based replacement therapy or antagonists to alter expression in colon cancer patient tumors.
Frequency of Mediterranean mutation among a group of Saudi G6PD patients in Western region‐Jeddah
- M. Gari, A. Chaudhary, S. Lary
- BiologyInternational Journal of Laboratory Hematology
- 1 February 2010
The frequency of exons 6 mutations responsible for G6PD deficiency (Mediterranean type) is reported for the first time from this region, with a figure of 50.1% and points to the low genetic diversity in the studied population.
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