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Changes in thiol content and expression of glutathione redox system genes in the hippocampus and cerebellum in Alzheimer's disease
Protein oxidation in the brain in Alzheimer's disease
Vitamin E protects against alcohol-induced cell loss and oxidative stress in the neonatal rat hippocampus
Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.
Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase‐related protein 2, α‐enolase and heat shock cognate 71
The dihydropyrimidinase related protein 2 (DRP‐2), which is involved in the axonal growth and guidance, showed significantly increased level in protein carbonyls in AD brain, suggesting a role for impaired mechanism of neural network formation in AD.
Oxidative Modification of Creatine Kinase BB in Alzheimer’s Disease Brain
- M. Aksenov, M. Aksenova, D. Butterfield, W. Markesbery
- Biology, ChemistryJournal of neurochemistry
- 1 June 2000
The analysis of specific protein carbonyl levels in CK BB, performed by two‐dimensional fingerprinting of oxidatively modified proteins, identified CK BB as one of the targets of protein oxidation in the AD brain.
Cocaine-mediated enhancement of Tat toxicity in rat hippocampal cell cultures: the role of oxidative stress and D1 dopamine receptor.
Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein Oxidation
The brain regional variation of these oxidation‐sensitive biomarkers corresponds to established histopathological features of AD and is paralleled by an increase in immunoreactive microglia, indicating that senile plaque‐dense regions of the AD brain may represent environments of elevated oxidative stress.
Reactive Oxygen Species as Causal Agents in the Neurotoxicity of the Alzheimer's Disease‐Associated Amyloid Beta Peptide a