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Biodegradable Nanoparticles as Vaccine Adjuvants and Delivery Systems: Regulation of Immune Responses by Nanoparticle-Based Vaccine
Polymeric nano- and microparticles have recently been shown to possess significant potential as drug delivery systems. In particular, the use of biodegrad- able polymeric nanoparticles with entrapped… Expand
Protein direct delivery to dendritic cells using nanoparticles based on amphiphilic poly(amino acid) derivatives.
Induction of an adaptive immune response by vaccination is possible for a broad range of infectious diseases or cancers. Antigen-loaded polymeric nanoparticles have recently been shown to possess… Expand
Preparation and characterization of apatite deposited on silk fabric using an alternate soaking process.
- T. Furuzono, T. Taguchi, A. Kishida, M. Akashi, Y. Tamada
- Medicine, Materials Science
- Journal of biomedical materials research
- 5 June 2000
Apatite-deposited silk fabric composite materials were developed using a new alternate soaking process. The characteristics of deposited apatite were studied using scanning electron microscopy (SEM),… Expand
Three-dimensional human tissue chips fabricated by rapid and automatic inkjet cell printing.
Alternating bioactivity of polymeric layer-by-layer assemblies: anticoagulation vs procoagulation of human blood.
The layer-by-layer assembly between cationic chitosan and anionic dextran sulfate was analyzed quantitatively by a quartz crystal microbalance technique in the absence and presence of 0.2, 0.5, and 1… Expand
In vitro enzymatic degradation of nanoparticles prepared from hydrophobically-modified poly(gamma-glutamic acid).
- T. Akagi, M. Higashi, T. Kaneko, T. Kida, M. Akashi
- Medicine, Chemistry
- Macromolecular bioscience
- 14 July 2005
Amphiphilic poly(gamma-glutamic acid) (gamma-PGA) was prepared by the introduction of L-phenylalanine ethylester (L-PAE) as a side chain. This gamma-PGA-graft-L-PAE formed monodispersed nanoparticles… Expand
Mucosal immunization with inactivated HIV-1-capturing nanospheres induces a significant HIV-1-specific vaginal antibody response in mice.
- Takami Akagi, M. Kawamura, +5 authors M. Baba
- Biology, Medicine
- Journal of medical virology
- 1 February 2003
Mucosal secretory IgA is considered to have an important role in the prevention of human immunodeficiency virus type 1 (HIV-1) transmission through sexual intercourse. Therefore, substances that… Expand
Novel functional biodegradable polymer IV: pH-sensitive controlled release of fibroblast growth factor-2 from a poly(gamma-glutamic acid)-sulfonate matrix for tissue engineering.
The acidic pH-sensitive controlled release of fibroblast growth factor-2 (FGF-2) from a biodegradable hydrogel without any denaturation of the FGF-2 was successfully performed by a combination of… Expand
Fusogenic liposome delivers encapsulated nanoparticles for cytosolic controlled gene release.
- J. Kunisawa, T. Masuda, +5 authors S. Nakagawa
- Chemistry, Medicine
- Journal of controlled release : official journal…
- 20 July 2005
Therapeutic agents based on DNA or RNA oligonucleotides (e.g., antisense DNA oligonucleotide, small interfering RNA) require a regulation of their kinetics in cytoplasm to maintain an optimal… Expand
Intracellular degradation and distribution of protein-encapsulated amphiphilic poly(amino acid) nanoparticles.
Physicochemical properties, such as particle size, shape, molecular weight, surface charge and composition, play a key role in the cellular uptake of polymeric nanoparticles. Antigen-encapsulated… Expand