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Biodegradable Nanoparticles as Vaccine Adjuvants and Delivery Systems: Regulation of Immune Responses by Nanoparticle-Based Vaccine
Polymeric nano- and microparticles have recently been shown to possess significant potential as drug delivery systems. In particular, the use of biodegrad- able polymeric nanoparticles with entrappedExpand
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Protein direct delivery to dendritic cells using nanoparticles based on amphiphilic poly(amino acid) derivatives.
Induction of an adaptive immune response by vaccination is possible for a broad range of infectious diseases or cancers. Antigen-loaded polymeric nanoparticles have recently been shown to possessExpand
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Preparation and characterization of apatite deposited on silk fabric using an alternate soaking process.
Apatite-deposited silk fabric composite materials were developed using a new alternate soaking process. The characteristics of deposited apatite were studied using scanning electron microscopy (SEM),Expand
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Three-dimensional human tissue chips fabricated by rapid and automatic inkjet cell printing.
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Alternating bioactivity of polymeric layer-by-layer assemblies: anticoagulation vs procoagulation of human blood.
The layer-by-layer assembly between cationic chitosan and anionic dextran sulfate was analyzed quantitatively by a quartz crystal microbalance technique in the absence and presence of 0.2, 0.5, and 1Expand
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In vitro enzymatic degradation of nanoparticles prepared from hydrophobically-modified poly(gamma-glutamic acid).
Amphiphilic poly(gamma-glutamic acid) (gamma-PGA) was prepared by the introduction of L-phenylalanine ethylester (L-PAE) as a side chain. This gamma-PGA-graft-L-PAE formed monodispersed nanoparticlesExpand
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Mucosal immunization with inactivated HIV-1-capturing nanospheres induces a significant HIV-1-specific vaginal antibody response in mice.
Mucosal secretory IgA is considered to have an important role in the prevention of human immunodeficiency virus type 1 (HIV-1) transmission through sexual intercourse. Therefore, substances thatExpand
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Novel functional biodegradable polymer IV: pH-sensitive controlled release of fibroblast growth factor-2 from a poly(gamma-glutamic acid)-sulfonate matrix for tissue engineering.
The acidic pH-sensitive controlled release of fibroblast growth factor-2 (FGF-2) from a biodegradable hydrogel without any denaturation of the FGF-2 was successfully performed by a combination ofExpand
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Fusogenic liposome delivers encapsulated nanoparticles for cytosolic controlled gene release.
Therapeutic agents based on DNA or RNA oligonucleotides (e.g., antisense DNA oligonucleotide, small interfering RNA) require a regulation of their kinetics in cytoplasm to maintain an optimalExpand
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Intracellular degradation and distribution of protein-encapsulated amphiphilic poly(amino acid) nanoparticles.
Physicochemical properties, such as particle size, shape, molecular weight, surface charge and composition, play a key role in the cellular uptake of polymeric nanoparticles. Antigen-encapsulatedExpand
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