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Biodegradable Nanoparticles as Vaccine Adjuvants and Delivery Systems: Regulation of Immune Responses by Nanoparticle-Based Vaccine
Polymeric nano- and microparticles have recently been shown to possess significant potential as drug delivery systems. In particular, the use of biodegrad- able polymeric nanoparticles with entrappedExpand
Protein direct delivery to dendritic cells using nanoparticles based on amphiphilic poly(amino acid) derivatives.
The results suggest that antigen-loaded gamma-hPGA nanoparticles provide a novel delivery tool for vaccination against viral infections or tumors, and has potential application as a universal delivery system for protein-based vaccines capable of inducing cytotoxic T lymphocytes. Expand
Induction of Potent CD8+ T-Cell Responses by Novel Biodegradable Nanoparticles Carrying Human Immunodeficiency Virus Type 1 gp120
ABSTRACT The mainstream of recent anti-AIDS vaccines is a prime/boost approach with multiple doses of the target DNA of human immunodeficiency virus type 1 (HIV-1) and recombinant viral vectors. InExpand
Preparation and characterization of apatite deposited on silk fabric using an alternate soaking process.
Apatite deposited on silk by the alternate soaking process was a deficient apatite containing carbonate, HPO(4)(2-), and Na(+) ions as in a natural bone tissue, which might be potentially bioactive. Expand
A novel strategy to engineer pre-vascularized 3-dimensional skin substitutes to achieve efficient, functional engraftment
It is proposed that a novel dermo-epidermal 3D skin substitute containing blood vessels can promote efficient reconstruction of full-thickness skin defects on severe combined immunodeficiency mice. Expand
Immunomodulatory nanoparticles as adjuvants and allergen-delivery system to human dendritic cells: Implications for specific immunotherapy.
This study demonstrates that 200-nm sized biodegradable poly(gamma-glutamic acid) (Gamma-PGA) nanoparticles (NPs) are activators of human monocyte-derived dendritic cells (MoDCs) and are promising as sophisticated adjuvants and allergen-delivery systems in allergenic-specific immunotherapy. Expand
Inkjet printing of layer-by-layer assembled poly(lactide) stereocomplex with encapsulated proteins.
This fabrication technique would provide a platform for creating protein/vaccine/gene delivery carriers with the desired release profiles by controlling the microphase-separated structure and drug distribution within the composites. Expand
Alternating bioactivity of polymeric layer-by-layer assemblies: anticoagulation vs procoagulation of human blood.
It is suggested that the polymer species and/or the assembly conditions are key factors for realizing the alternating bioactivities of films prepared by the layer-by-layer assembly. Expand