• Publications
  • Influence
Sedative, antiepileptic and antipsychotic effects of Spondias mombin L. (Anacardiaceae) in mice and rats.
The effect of the extracts on hexobarbitone-induced sleeping time was blocked by flumazenil a GABA(A) antagonist, indicating that the extracts contain GABA( A) agonists. Expand
Selective stimulation of orexin receptor type 2 promotes wakefulness in freely behaving rats
The arousal effects of newly developed selective orexin receptor type 2 agonist, [Ala11]orexin-B, on the sleep-wake cycle in rats are determined and suggest that orexins A and B plays an important role in the modulation of sleep- wake state and behavioral responses. Expand
Psychoneuropharmacological activities and chemical composition of essential oil of fresh fruits of Piper guineense (Piperaceae) in mice.
The most abundant component of the fresh fruits essential oil of P. guineense was β-sesquiphellandrene (20.9%); and the oil possesses CNS depressant, hypothermic, sedative, muscle relaxant, antipsychotic and anticonvulsant activities, thus providing scientific basis for its ethnomedicinal applications. Expand
Hypnotic, anticonvulsant and anxiolytic effects of 1-nitro-2-phenylethane isolated from the essential oil of Dennettia tripetala in mice.
1-nitro-2-phenylethane exhibited dose dependent significant hypnotic, anticonvulsant and anxiolytic effects and it is the compound largely responsible for the neuropharmacological effects of the oil. Expand
Neuropharmacological effects of oleamide in male and female mice
Oleamide has antidepressant-like property and acute triple intraperitoneal administration of oleamide at 10mg/kg induced a significant reduction in the immobility duration in mice signifying an antidepressant effect. Expand
Evidence of alterations in brain structure and antioxidant status following 'low-dose' monosodium glutamate ingestion.
OBJECTIVE The study investigated the effects of low dose monosodium glutamate (MSG) on the brain, with a view to providing information on its effects on neuronal morphology and antioxidant status inExpand
Changes in Spontaneous Working-memory, Memory-recall and Approach-avoidance following “Low Dose” Monosodium Glutamate in Mice
The study investigated the effects of ‘low doses’ of monosodium glutamate (MSG) on hippocampal-related (spontaneous working-memory, memory-recall and anxiety) behaviours, and hippocampalExpand
Anxiolytic and antidepressant like effects of natural food flavour (E)-methyl isoeugenol.
The findings demonstrated anxiolytic and antidepressant like properties of (E)-methyl isoeugenol and suggested the participation of serotonergic pathways. Expand
Foraging enrichment modulates open field response to monosodium glutamate in mice
Behavioural response to varying doses of MSG as observed in the open field is affected by modifications such as foraging enrichment, which can reverse or dampen the central effects seen irrespective of duration of administration. Expand
Neuropeptide-Y Y2-receptor agonist, PYY3–36 promotes non-rapid eye movement sleep in rat
Investigation of the effects of nocturnal intraperitoneal administration of single doses of PYY3-36 on food intake, water intake and the sleep-wake cycle in rats suggests that the drug may play an important role in the enhancement of NREM sleep and feeding behavior. Expand