Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors.
- I. Endo, D. Inoue, Toshio Matsumoto
- Biology, MedicineEndocrinology
- 1 December 2003
The present study finds that each muscle fiber was small and variable in size in hindlimb skeletal muscle from VDR -/- mice, although overall myocyte differentiation occurred normally, suggesting that VDR plays a physiological role in skeletal muscle development, participating in temporally strict down-regulation of myoregulatory transcription factors.
Parkin enhances mitochondrial biogenesis in proliferating cells.
- Y. Kuroda, T. Mitsui, Toshio Matsumoto
- BiologyHuman Molecular Genetics
- 15 March 2006
Results indicate that parkin is involved in the regulation of mitochondrial transcription/replication other than the ubiquitin-mediated protein degradation system in proliferating cells.
Coronary atherosclerosis is associated with macrophage polarization in epicardial adipose tissue.
Regulation of Epidermal Growth Factor-induced Connexin 43 Gap Junction Communication by Big Mitogen-activated Protein Kinase 1/ERK5 but Not ERK1/2 Kinase Activation*
- S. Cameron, S. Malik, J. Yang
- BiologyJournal of Biological Chemistry
- 16 May 2003
BMK1 is more important than ERK1/2 in EGF-mediated Cx43 gap junction uncoupling by association and Cx 43 Ser- 255 phosphorylation, and by co-immunoprecipitation, it is found that BMK1 directly associates with CX43 in vivo.
Hyperactivity and spatial maze learning impairment of adult rats with temporary neonatal hypothyroidism.
- M. Akaike, N. Kato, H. Ohno, T. Kobayashi
- Psychology, BiologyNeurotoxicology and Teratology
- 1 May 1991
Disruption of Nuclear Vitamin D Receptor Gene Causes Enhanced Thrombogenicity in Mice*
- K. Aihara, H. Azuma, Toshio Matsumoto
- Biology, MedicineJournal of Biological Chemistry
- 20 August 2004
It is demonstrated that activation of nuclear VDR elicits antithrombotic effects in vivo, and suggested that the VDR system may play a physiological role in the maintenance of antithROMbotic homeostasis.
Glucocorticoid Excess Induces Superoxide Production in Vascular Endothelial Cells and Elicits Vascular Endothelial Dysfunction
- Takahiko Iuchi, M. Akaike, Toshio Matsumoto
- Biology, MedicineCirculation Research
- 10 January 2003
It is suggested that GC excess causes overproduction of ROS and thereby perturbs NO availability in the vascular endothelium, leading to vascular complications in patients with GC excess.
Enhanced inflammation in epicardial fat in patients with coronary artery disease.
It is suggested that inflammatory cell infiltration is enhanced in epicardial adipose tissue, but not in subcutaneous fat, in patients with coronary artery disease.
The hinge-helix 1 region of peroxisome proliferator-activated receptor gamma1 (PPARgamma1) mediates interaction with extracellular signal-regulated kinase 5 and PPARgamma1 transcriptional activation:…
ERK5 mediates flow- and ligand-induced PPARgamma activation via the interaction of ERK5 with the hinge-helix 1 region of PP ARgamma, suggesting a physiological role for ERK 5 and PPARGamma activation in flow-mediated antiinflammatory effects.
Changed preference for sweet taste in adulthood induced by perinatal exposure to bisphenol A-A probable link to overweight and obesity.
- Xiaobin Xu, Luei Tan, N. Kato
- Biology, MedicineNeurotoxicology and Teratology
- 1 July 2011