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Regulation of Interleukin-1β-induced Interleukin-6 Gene Expression in Human Fibroblast-like Synoviocytes by p38 Mitogen-activated Protein Kinase*
TLDR
Evidence is provided that p38 MAP kinase is activated in response to IL-1β in human FLSs and is involved in IL-6 synthesis by stabilizing IL- 6 mRNA. Expand
Effects of β3‐adrenoceptor stimulation on prostaglandin E2–induced bladder hyperactivity and on the cardiovascular system in conscious rats
TLDR
To investigate the effects of selective β2‐ and selective β3‐adrenoceptor (AR) agonists on prostaglandin (PG) E2‐induced bladder hyperactivity in conscious free‐moving rats, two new selective agonists were developed. Expand
Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB.
TLDR
It is found that bezafibrate was a ligand for PPARalpha, delta, and gamma in the CARLA and that befibrate induced transcriptional activation of PPAR alpha/RXRalpha, PPARdelta/R XR alpha, and PPARgamma/RxRalpha. Expand
Role of gastric motility in development of stress-induced gastric lesions of rats.
TLDR
It is concluded that increased gastric motility is closely associated with marked formation of gastric lesions under conditions of restraint and water immersion stress and is probably a main cause for their vigorous formation, although formation of lesions occurs to a small degree without involvement of gastrics motility. Expand
Adiponectin receptor 2 expression in liver and insulin resistance in db/db mice given a beta3-adrenoceptor agonist.
TLDR
The results suggest that the increased plasma adiponectin levels seen in db/db mice treated with this beta3-adrenoceptor agonist induce a down-regulation of adip onectin receptor 2 mRNA expression specifically in the liver. Expand
Participation of thromboxane A2 in the cough response in guinea‐pigs: antitussive effect of ozagrel
TLDR
Results show that TXA2 modulates the capsaicin‐induced cough response by increasing capsaicIn‐sensitivity. Expand
Existence of a beta3-adrenoceptro and its functional role in the human ureter.
TLDR
The present results provide the first evidence that the beta3-AR subtype is distributed in human ureteral smooth muscle and that it, and beta2-AR, mediate the ureTERal relaxation induced by adrenergic stimulation. Expand
Fibrate and Statin Synergistically Increase the Transcriptional Activities of PPARα/RXRα and Decrease the Transactivation of NFκB
TLDR
It is found that bezafibrate was a ligand for PPARα, δ, and γ in the CARLA and that befibrate induced transcriptional activation of PPAR α/RXRα, PPARδ/R XR α, and PPARγ/RxRα. Expand
Functional Characterization of β-adrenoceptor Subtypes in the Canine and Rat Lower Urinary Tract
TLDR
In the dog the relaxing effects of isoprenaline in the distal urethra were about half those seen in the detrusor and trigone, and the maximal relaxation to each agonist wa... Expand
Characterization of beta-adrenoceptor subtype in bladder smooth muscle in cynomolgus monkey.
TLDR
The present functional study provides the first evidence that relaxation of the monkey detrusor by beta-adrenoceptor activation is mediated via the beta3-subtype. Expand
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