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Structural conversion of neurotoxic amyloid-β(1–42) oligomers to fibrils
The amyloid-β1–42 (Aβ42) peptide rapidly aggregates to form oligomers, protofibils and fibrils en route to the deposition of amyloid plaques associated with Alzheimer's disease. We show thatExpand
High-resolution atomic force microscopy of soluble Abeta42 oligomers.
Soluble oligomers and protofibrils are widely thought to be the toxic forms of the Abeta42 peptide associated with Alzheimer's disease. We have investigated the structure and formation of theseExpand
Fusion of Cells by Flipped SNAREs
The SNARE (soluble N-ethylmaleimide–sensitive factor attachment protein receptor) hypothesis suggests that pairs of proteins known as vesicle (v-) SNAREs and target membrane (t-) SNAREs interactExpand
FKBP12 binds to acylated H-ras and promotes depalmitoylation.
A cycle of palmitoylation/depalmitoylation of H-Ras mediates bidirectional trafficking between the Golgi apparatus and the plasma membrane, but nothing is known about how this cycle is regulated. WeExpand
Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42.
Amyloid fibrils associated with Alzheimer's disease and a wide range of other neurodegenerative diseases have a cross beta-sheet structure, where main chain hydrogen bonding occurs betweenExpand
Degradation of Amyloid β Protein by Purified Myelin Basic Protein*
The progressive accumulation of β-amyloid (Aβ) in senile plaques and in the cerebral vasculature is the hallmark of Alzheimer disease and related disorders. Impaired clearance of Aβ from the brainExpand
Probing the architecture of the B. subtilis RNase P holoenzyme active site by cross-linking and affinity cleavage.
Bacterial ribonuclease P (RNase P) is a ribonucleoprotein complex composed of one catalytic RNA (PRNA) and one protein subunit (P protein) that together catalyze the 5' maturation of precursor tRNA.Expand
Engineering anti‐GD2 monoclonal antibodies for cancer immunotherapy
Ganglioside GD2 is highly expressed on neuroectoderm‐derived tumors and sarcomas, including neuroblastoma, retinoblastoma, melanoma, small cell lung cancer, brain tumors, osteosarcoma,Expand
Humanized Affinity-matured Monoclonal Antibody 8H9 Has Potent Antitumor Activity and Binds to FG Loop of Tumor Antigen B7-H3*
Background: B7-H3 is an immune inhibitory ligand and an antigen on many solid tumors. Results: Antibody 8H9 was humanized and affinity-matured, and its epitope was mapped to the FG loop of B7-H3.Expand
N-terminal Domain of Myelin Basic Protein Inhibits Amyloid β-Protein Fibril Assembly*
Accumulation of amyloid β-protein (Aβ) into brain parenchymal plaques and the cerebral vasculature is a pathological feature of Alzheimer disease and related disorders. Aβ peptides readily formExpand