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Serine and glycine metabolism in cancer☆
TLDR
A novel anticancer therapy is aiming to target serine and glycine biosynthesis, which are essential metabolites for cancer cells and provide precursors for macromolecules and antioxidant defence. Expand
Frontline: GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations
TLDR
The results show that the proliferation response of CD8+ and CD4+ peripheral T cell subpopulations was potentiated when a GITR costimulus was added to an anti‐CD3 stimulus, suggesting a novel function for G ITR as costimulatory molecule of T cell subsets. Expand
Zinc-finger proteins in health and disease
TLDR
A comprehensive summary of the current state of knowledge of zinc-finger proteins, their structure and functions is provided and the biological role of ZNFs in the development of organisms under normal physiological and pathological conditions is focused on. Expand
GILZ mediates the antiproliferative activity of glucocorticoids by negative regulation of Ras signaling.
TLDR
Findings indicate that GILZ serves as a negative regulator of Ras- and Raf-induced proliferation and is an important mediator of the antiproliferative effect of GCs. Expand
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer
TLDR
It is suggested that p63/miR-205 may be a useful clinical predictor of metastatic behavior in prostate cancer and loss of this axis was associated with higher Gleason scores, an increased likelihood of metastasis and infiltration events, and worse prognosis. Expand
Increased GILZ expression in transgenic mice up-regulates Th-2 lymphokines.
TLDR
It is demonstrated that Gilz contributes to CD4+ commitment toward a Th-2 phenotype and suggested this contribution may be another mechanism accounting for glucocorticoid immunomodulation. Expand
miR-146a is modulated in human endothelial cell with aging.
TLDR
A miR-146a is identified that is progressively modulated in endothelial cells with aging and involved in a premature senescence-like phenotype through direct targeting of the NOX4 protein, implicated in cellsenescence and aging. Expand
miR-7 and miR-214 are specifically expressed during neuroblastoma differentiation, cortical development and embryonic stem cells differentiation, and control neurite outgrowth in vitro.
TLDR
A comparative study of miR expression profiles in neuroblastoma, in cortical development, and in neuronal differentiation of embryonic stem (ES) cells is presented and it is shown thatmiR-7 and miR-214 are modulated in neurons differentiation, and control neurite outgrowth in vitro. Expand
microRNA-34a regulates neurite outgrowth, spinal morphology, and function
TLDR
It is shown that the TAp73/miR-34a axis is retained in mouse ES cells committed to differentiate toward a neurological phenotype and results in electrophysiological changes consistent with a reduction in spinal function. Expand
Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets
TLDR
It is shown that p73 drives the expression of microRNA (miR)-34a, but not miR-34b and -c, by acting on specific binding sites on the miR -34a promoter, which reinforces a role for TAp73 in neuronal development. Expand
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