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Structural basis of BMP signalling inhibition by the cystine knot protein Noggin
The crystal structure of the antagonist Noggin bound to BMP-7 is reported, which shows that Nogsgin inhibits BMP signalling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors. Expand
Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex.
It is shown that a conserved N-terminal domain of HTH directly binds to EXD in vitro, and is sufficient to induce the nuclear localization ofEXD in vivo, however, mutating a key DNA binding residue in the HTH homeodomain abolishes many of its in vivo functions. Expand
Fluorescent fusion protein knockout mediated by anti-GFP nanobody
The use of genetic mutations to study protein functions in vivo is a central paradigm of modern biology. Recent advances in reverse genetics such as RNA interference and morpholinos are widely used… Expand
The Decapentaplegic morphogen gradient: from pattern formation to growth regulation
How different experimental approaches have led to an unprecedented level of molecular knowledge about the patterning role of the Drosophila melanogaster morphogen Decapentaplegic (DPP), the homologue of vertebrate bone morphogenetic protein, or BMP, the first validated secreted morphogen, is reviewed. Expand
Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic
It is proposed that specification of distinct cell fates in response to different concentrations of dpp may be achieved combinatorially by the sax and tkv receptors. Expand
Hox proteins meet more partners.
The Hox genes are clustered sets of homeobox-containing genes that play a central role in animal development and suggest that Hox proteins interact with pre-existing homeodomain protein complexes to regulate Hox activity and Hox specificity. Expand
Control of Dpp morphogen signalling by a secreted feedback regulator
- Robin Vuilleumier, Alexander Springhorn, +4 authors G. Pyrowolakis
- Biology, Medicine
- Nature Cell Biology
- 9 May 2010
It is revealed that pentagone (pent), a transcriptional target of BMP signalling encoding a secreted regulator of the pathway, interacts with the glypican Dally to control Dpp distribution and provides evidence that proper establishment of the BMP morphogen gradient requires the inbuilt feedback loop embodied by Pent. Expand
An absolute requirement for both the type II and type I receptors, punt and thick veins, for Dpp signaling in vivo
It is demonstrated that punt, like tkv, is essential in vivo for dpp-dependent patterning processes and that both receptors act in concert to transduce the dpp signal and that their functions cannot be replaced by the other extant type II and I receptors. Expand