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The Amphimedon queenslandica genome and the evolution of animal complexity
Comparative analysis enabled by the sequencing of the sponge genome reveals genomic events linked to the origin and early evolution of animals, including the appearance, expansion and diversification of pan-metazoan transcription factor, signalling pathway and structural genes.
Deep metazoan phylogeny: when different genes tell different stories.
Developmental gene expression provides clues to relationships between sponge and eumetazoan body plans.
Analysis of expression of a broad range of eumetazoan developmental regulatory genes in Sycon ciliatum provides a framework for further studies aimed at deciphering ancestral developmental regulatory networks and their modifications during animal body plans evolution.
The NK Homeobox Gene Cluster Predates the Origin of Hox Genes
A Post-Synaptic Scaffold at the Origin of the Animal Kingdom
Highly conserved protein interaction motifs and co-expression in sponges of multiple proteins whose homologs interact in eumetazoan synapses indicate that a complex protein scaffold was present at the origin of animals, perhaps predating nervous systems.
Wnt and TGF-β Expression in the Sponge Amphimedon queenslandica and the Origin of Metazoan Embryonic Patterning
The radially symmetrical expression patterns of Wnt and TGF-β along the anterior-posterior axis of sponge embryos and larvae suggest that these signalling pathways contributed to establishing axial polarity in the very first metazoans.
Structure and expression of conserved Wnt pathway components in the demosponge Amphimedon queenslandica
The results indicate that the Wnt–β‐catenin pathway was used in embryonic patterning in the last common ancestor of living metazoans and is observed in extant bilaterian animals.
FGFs control the patterning of the inner ear but are not able to induce the full ear program
Plasticity of Animal Genome Architecture Unmasked by Rapid Evolution of a Pelagic Tunicate
It is shown that multiple genomic features including transposon diversity, developmental gene repertoire, physical gene order, and intron-exon organization are shattered in the tunicate Oikopleura, belonging to the sister group of vertebrates and retaining chordate morphology.