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The Amphimedon queenslandica genome and the evolution of animal complexity
Sponges are an ancient group of animals that diverged from other metazoans over 600 million years ago. Here we present the draft genome sequence of Amphimedon queenslandica, a demosponge from theExpand
Deep metazoan phylogeny: when different genes tell different stories.
Molecular phylogenetic analyses have produced a plethora of controversial hypotheses regarding the patterns of diversification of non-bilaterian animals. To unravel the causes for the patterns ofExpand
A Post-Synaptic Scaffold at the Origin of the Animal Kingdom
Background The evolution of complex sub-cellular structures such as the synapse requires the assembly of multiple proteins, each conferring added functionality to the integrated structure. TrackingExpand
The NK Homeobox Gene Cluster Predates the Origin of Hox Genes
Hox and other Antennapedia (ANTP)-like homeobox gene subclasses - ParaHox, EHGbox, and NK-like - contribute to key developmental events in bilaterians [1-4]. Evidence of physical clustering of ANTPExpand
Plasticity of Animal Genome Architecture Unmasked by Rapid Evolution of a Pelagic Tunicate
Ocean Dweller Sequenced The Tunicates, which include the solitary free-swimming larvaceans that are a major pelagic component of our oceans, are a basal lineage of the chordates. In order toExpand
Wnt and TGF-β Expression in the Sponge Amphimedon queenslandica and the Origin of Metazoan Embryonic Patterning
Background The origin of metazoan development and differentiation was contingent upon the evolution of cell adhesion, communication and cooperation mechanisms. While components of many of the majorExpand
Structure and expression of conserved Wnt pathway components in the demosponge Amphimedon queenslandica
SUMMARY Wnt‐signalling plays a critical role in animal development, and its misregulation results in serious human diseases, including cancer. While the Wnt pathway is well studied in eumetazoanExpand
Developmental gene expression provides clues to relationships between sponge and eumetazoan body plans.
Elucidation of macroevolutionary transitions between diverse animal body plans remains a major challenge in evolutionary biology. We address the sponge-eumetazoan transition by analyzing expressionExpand
FGFs control the patterning of the inner ear but are not able to induce the full ear program
FGF2 or FGF8 applied ectopically, close to the developing otic placode enhances transcription of a subset of ear marker genes such as Nkx5-1, SOHo1 and Pax2. Other ear expressed genes (Dlx5 and BMP4)Expand
Early evolution of the T-box transcription factor family
Significance The T-box transcription factors are key players in animal development and they were considered strictly animal-specific. We show that T-box genes have instead an important premetazoanExpand