• Publications
  • Influence
Medicinal herbs for the treatment of rheumatic disorders--a survey of European herbals from the 16th and 17th century.
European herbals may be a valuable source of information for the selection of plants for focussed screening programmes and information contained in these herbals should be explored in a systematic manner.
In vitro screening of traditional South African malaria remedies against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum.
Three hundred extracts were prepared from plants traditionally used in South Africa to treat malaria and screened in vitro for activity against Trypanosoma brucei rhodesiense, TryPanosoma cruzi, Leishmania donovani, and Plasmodium falciparum, finding notable results against all four protozoal parasites.
Plants traditionally used in age related brain disorders--a survey of ethnobotanical literature.
This review of available literature from four Swiss university libraries, scientific journals and online database query's on plants and remedies used in traditional medicinal systems for such diseases relevant to dementia and Alzheimer's disease found over 150 plant species in various preparations and mixtures.
In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica.
Structures of abietane diterpenoid quinones are established on the basis of one and two dimensional nuclear magnetic resonance spectroscopic data, electron ionization mass spectrometric analysis (EIMS) as well as comparison with data from literature.
Antiplasmodial lanostanes from the Ganoderma lucidum mushroom.
Seven lanostanes exhibited in vitro antiplasmodial activity with IC(50) values from 6 to greater than 20 microM and a new benzofuran derivative of the farnesyl hydroquinone ganomycin B was also identified.
Inhibition of leukotriene biosynthesis by stilbenoids from Stemona species.
Fifteen stilbenoids and two alkaloids from Stemona collinsae, S. tuberosa, and S. peirrei were tested alongside the commercially available stilbenoids resveratrol and pinosylvin for inhibition of
Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation.
Structural-activity relationship studies showed that the polarity of the derivatives plays a crucial role in their activity towards COX-1/2 enzyme and 5-LOX mediated LTB(4) formation.
Antiprotozoal screening of 60 South African plants, and the identification of the antitrypanosomal germacranolides schkuhrin I and II.
HPLC-based activity profiling was used to identify the active constituents in the extracts, and the germacranolide sesquiterpene lactones schkuhrin I and II from S. pinnata, and cynaropicrin from V. mespilifolia were identified, with IC50 values of 0.9, 1.5, and 0.23 µM, respectively.
Knipholone, a selective inhibitor of leukotriene metabolism.
The leukotriene biosynthesis inhibitory effect of knipholone was evident by its ability either to inhibit the 5-lipoxygenase activating protein (FLAP) or as a competitive (non-redox) inhibitor of the enzyme.
Activities of Psilostachyin A and Cynaropicrin against Trypanosoma cruzi In Vitro and In Vivo
The data demonstrate that although it is very promising against African trypanosomes, cynaropicrin does not show efficacy compared to benznidazole in acute mouse models of T. cruzi infection.