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Functional MRI evidence for adult motor cortex plasticity during motor skill learning
- A. Kami, G. Meyer, P. Jezzard, M. Adams, R. Turner, Leslie G. Ungerleider
- Biology, PsychologyNature
- 14 September 1995
A slowly evolving, long-term, experience-dependent reorganization of the adult Ml is suggested, which may underlie the acquisition and retention of the motor skill.
The acquisition of skilled motor performance: fast and slow experience-driven changes in primary motor cortex.
- A. Karni, G. Meyer, Leslie G. Ungerleider
- Psychology, BiologyProceedings of the National Academy of Sciences…
- 3 February 1998
It is shown that a few minutes of daily practice on a sequential finger opposition task can be sufficient to trigger performance gains that require time to become evident, and proposed that skilled motor performance is acquired in several stages: "fast" learning, an initial, within-session improvement phase, followed by a period of consolidation of several hours duration, and then "slow" learnings, consisting of delayed, incremental gains in performance emerging after continued practice.
Experience-dependent changes in cerebellar contributions to motor sequence learning
- J. Doyon, A. Song, A. Karni, F. Lalonde, M. Adams, Leslie G. Ungerleider
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 22 January 2002
Results indicate that intrinsic modulation within the cerebellum, in concert with activation of motor-related cortical regions, serves to set up a procedurally acquired sequence of movements that is then maintained elsewhere in the brain.
Circuit-Specific Alterations in Hippocampal Synaptophysin Immunoreactivity Predict Spatial Learning Impairment in Aged Rats
- Thressa D. Smith, M. Adams, M. Gallagher, J. Morrison, P. Rapp
- Biology, PsychologyThe Journal of Neuroscience
- 1 September 2000
These findings are the first to demonstrate that a circuit-specific pattern of variability in the connectional organization of the hippocampus is coupled to individual differences in the cognitive outcome of normal aging.
Visual cortical projections and chemoarchitecture of macaque monkey pulvinar
- M. Adams, P. Hof, R. Gattass, M. Webster, Leslie G. Ungerleider
- BiologyThe Journal of comparative neurology
- 10 April 2000
The results suggest that CB may further delineate functional subdivisions in the pulvinar, and that the calbindin‐rich and ‐poor regions of P3 corresponded to differential patterns of cortical connectivity.
Estrogen and Aging Affect the Subcellular Distribution of Estrogen Receptor-α in the Hippocampus of Female Rats
The data suggest that the decreased responsiveness of hippocampal synapses to estrogen in aged animals may result from age-related decrements in ER-α levels and its subcellular localization vis-à-vis the synapse.
Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability
Estrogen modulates synaptic N‐methyl‐D‐aspartate receptor subunit distribution in the aged hippocampus
- M. Adams, Susan E Fink, W. Janssen, Ravi A. Shah, J. Morrison
- BiologyThe Journal of comparative neurology
- 28 June 2004
Investigating the effect of estrogen on the synaptic and subsynaptic distributions of the NMDA receptor subunits, NR2A and NR2B in CA1 pyramidal cells, demonstrated that the overall synaptic levels are similar in young and aged female rats, regardless of estrogen treatment, and suggested that estrogen may impact the mobility of NMDA receptors across the synapse and restore a more youthful synaptic profile.
Spatial Learning and Memory Deficits after Whole-Brain Irradiation are Associated with Changes in NMDA Receptor Subunits in the Hippocampus
A clinically relevant regimen of fractionated whole-brain irradiation led to significant impairments in spatial learning and reference memory and alterations in the relative levels of subunits of the NMDA, but not the AMPA, receptors in hippocampal CA1, suggesting for the first time that radiation-induced cognitive impairments may be associated with alterations in glutamate receptor composition.
Functional characterization of des-IGF-1 action at excitatory synapses in the CA1 region of rat hippocampus.
- M. Ramsey, M. Adams, O. Ariwodola, W. Sonntag, J. Weiner
- BiologyJournal of neurophysiology
- 1 July 2005
This characterization of the acute actions of des-IGF-1 at hippocampal excitatory synapses may provide insight into the mechanism by which long-term increases in plasma IGF-1 impart cognitive benefits in aged rats.