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Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron.
- R. Hrdina, V. Geršl, Ivona Klimtová, T. Šimůnek, Jarmila Machácková, M. Adamcová
- Biology, ChemistryActa medica
Modification of dosage schedule and synthesis of new anthracycline analogues may represent alternative approaches to mitigate anthrACYcline cardiotoxicity while preserving antitumour activity.
Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats
- F. Simko, O. Pechanova, L. Paulis
- Biology, MedicineJournal of hypertension. Supplement : official…
- 1 August 2009
Although melatonin, in comparison with captopril, did not reverse left ventricle hypertrophy, it reversed left ventricular fibrosis and this protection by melatonin may be caused by its prominent antioxidative effect.
Continuous light and L-NAME-induced left ventricular remodelling: different protection with melatonin and captopril
In hypertension induced by a combination of continuous light and L-NAME treatment, melatonin and captopril protect the heart against pathological left ventricular remodelling differently.
Veterinary and toxicological applications for the detection of cardiac injury using cardiac troponin.
Molecular Remodeling of Left and Right Ventricular Myocardium in Chronic Anthracycline Cardiotoxicity and Post-Treatment Follow Up
Chronic anthracycline cardiotoxicity is a serious clinical issue with well characterized functional and histopathological hallmarks. However, molecular determinants of the toxic damage and associated…
Melatonin improves the restoration of endothelium-derived constricting factor signalling and inner diameter in the rat femoral artery after cessation of L-NAME treatment
Although melatonin did not accelerate blood pressure reduction, it attenuated EDCF-contractions and oxidative load and enlarged arterial diameter and may be beneficial for cardiovascular protection.
Proteomic insights into chronic anthracycline cardiotoxicity.
Melatonin reduces cardiac remodeling and improves survival in rats with isoproterenol‐induced heart failure
Melatonin exerts cardioprotective effects and improves outcome in a model of isoproterenol‐induced heart damage and the antiremodeling effect of melatonin may be of potential benefit in patients with heart failure.