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In vivo characterization of a specific cannabinoid receptor antagonist (SR141716A): inhibition of delta 9-tetrahydrocannabinol-induced responses and apparent agonist activity.
It is not clear whether this pharmacological activity represents an uncharacterized action of SR141716A, or an index of tonic activity of an endogenous cannabinergic system, but it will be useful in establishing the biochemical events responsible for the in vivo effects of exogenous cannabinoids, as well as inestablishing the existence of a putative endogenous cannabinoidergic system.
Pharmacological properties of JDTic: a novel kappa-opioid receptor antagonist.
JDTic is the first potent kappa-selective opioid receptor antagonist not derived from an opiate class of compounds and fails to antagonize the analgesic effects of the selective MOP mu-opioid receptor agonists.
Discriminative stimulus, reinforcing, physical dependence, and antinociceptive effects of oxycodone in mice, rats, and rhesus monkeys.
The results suggest that the analgesic and abuse liability effects of oxycodone are likely mediated through mu-opioid receptors and provide the first laboratory report of its discriminative stimulus, reinforcing, and morphine cross-dependency effects.
Dependence on delta 9-tetrahydrocannabinol: studies on precipitated and abrupt withdrawal.
Evidence is provided that a modest course of delta 9-tetrahydrocannabinol can produce physical dependence and the risk and incidence of marijuana dependence in humans may be greater than previously projected.
NIH 11082 produces anti-depressant-like activity in the mouse tail-suspension test through a delta-opioid receptor mechanism of action.
The results reinforce the notion that delta-opioid receptor agonists can produce significant effects in a behavioral model used to screen anti-depressant drugs.
Nicotine-induced antinociception in rats and mice: correlation with nicotine brain levels.
The data implicate several different mechanisms in the antinociceptive action of nicotine, which appeared to be central in both rats and mice inasmuch as mecamylamine antagonized completely but hexamethonium (5 mg/kg) antagonized partially.
Comparative pharmacology of nicotine and ABT-418, a new nicotinic agonist
Although activation of nicotinic receptors by ABT-418 produced several behavioral and pharmacological effects, the results do not suggest high selectivity of different effects as reported by Decker et al. (1994) and Garvey et al (1994).