M. Aceto

Publications173
h-index32
Citations3,632
Highly Influential Citations111
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In vivo characterization of a specific cannabinoid receptor antagonist (SR141716A): inhibition of delta 9-tetrahydrocannabinol-induced responses and apparent agonist activity.
SR141716A has been described as a cannabinoid receptor antagonist. This study was conducted to determine whether SR141716A was capable of antagonizing the pharmacological effects of the prototypical… Expand
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Spontaneous and precipitated withdrawal with a synthetic cannabinoid, WIN 55212-2.
Physical dependence on the synthetic cannabinoid-receptor agonist R(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl) methanone mesylate (WIN… Expand
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Pharmacological properties of JDTic: a novel kappa-opioid receptor antagonist.
Biological studies were conducted on (3R)-7-Hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-1,2,3,4-tetrahydro-3-isoquinoline-carboxamide (JDTic),… Expand
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Pharmacological properties of JDTic: a novel κ-opioid receptor antagonist
Abstract Biological studies were conducted on (3 R )-7-Hydroxy- N -{(1 S )-1-{[(3 R ,4 R… Expand
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Discriminative stimulus, reinforcing, physical dependence, and antinociceptive effects of oxycodone in mice, rats, and rhesus monkeys.
Despite oxycodone's (4,5-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one) history of clinical use and the attention it has received as a drug of abuse, few reports have documented its… Expand
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Dependence on delta 9-tetrahydrocannabinol: studies on precipitated and abrupt withdrawal.
A cannabinoid antagonist, SR 141716A, dose dependently precipitated a behavioral withdrawal syndrome in rats continuously infused i.p. for only 4 days with relatively low-dose regimens of delta… Expand
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NIH 11082 produces anti-depressant-like activity in the mouse tail-suspension test through a delta-opioid receptor mechanism of action.
The present study examined the effects of NIH 11082 ((-)-(1R,5R,9R)-5,9-dimethyl-2'-hydroxy-2-(6-hydroxyhexyl)-6,7-benzomorphan hydrochloride), a benzomorphan analogue, in the mouse tail-suspension,… Expand
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Nicotine-induced antinociception in rats and mice: correlation with nicotine brain levels.
Nicotine was found to be potent in producing antinociception in mice and rats as measured by tail-flick latency but its action was of short duration. Nicotine's ED50 values (confidence limits) were… Expand
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Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR 141716A.
Precipitated withdrawal in rats chronically exposed to delta 9-tetrahydrocannabinol, the major psychoactive principle of the marijuana plant, was unequivocally demonstrated for the first time using a… Expand
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Antinociceptive action of nicotine and its methiodide derivatives in mice and rats
1 Three quaternary methiodides of nicotine were prepared and tested for antinociceptive activity in the mouse tail‐flick, mouse phenylquinone and rat tail‐flick tests. 2 Following peripheral… Expand
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