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Molecular characterization of a peripheral receptor for cannabinoids
THE major active ingredient of marijuana, Δ9-tetrahydrocannabi-nol (Δ9-THC), has been used as a psychoactive agent for thousands of years. Marijuana, and Δ9-THC, also exert a wide range of other… Expand
Nuclear Translocation of Extradenticle Requires homothorax , which Encodes an Extradenticle-Related Homeodomain Protein
We show that homothorax (hth) is required for the Hox genes to pattern the body of the fruit fly, Drosophila melanogaster. hth is necessary for the nuclear localization of an essential HOX cofactor,… Expand
Generation of multiple antagonistic domains along the proximodistal axis during Drosophila leg development.
homothorax (hth) is a Drosophila member of the Meis family of homeobox genes. hth function is required for the nuclear localization of the Hox cofactor Extradenticle (EXD). We show here that there is… Expand
Control of the nuclear localization of Extradenticle by competing nuclear import and export signals.
The Drosophila PBC protein Extradenticle (Exd) is regulated at the level of its subcellular distribution: It is cytoplasmic in the absence of Homothorax (Hth), a Meis family member, and nuclear in… Expand
Antagonism between extradenticle function and Hedgehog signalling in the developing limb
- S. González-Crespo, M. Abu-Shaar, M. Torres, C. Martínez-A, R. Mann, G. Morata
- Biology, Medicine
- 9 July 1998
The Drosophila homeobox gene extradenticle (exd) encodes a highly conserved cofactor of Hox proteins. exd activity is regulated post-translationally by a mechanism involving nuclear translocation,;… Expand
Nuclear import of the homeodomain protein Extradenticle in response to Wg and Dpp signalling
IN Drosophila, Decapentaplegic (Dpp)1 and Wingless (Wg)2 are two secreted signalling proteins of the transforming growth factor (TGF)-β and Wnt families, respectively. Although both are often… Expand
Engrailed cooperates with extradenticle and homothorax to repress target genes in Drosophila
Engrailed is a key transcriptional regulator in the nervous system and in the maintenance of developmental boundaries in Drosophila, and its vertebrate homologs regulate brain and limb development.… Expand
From the Bench to the Pharmacy: Protecting Innovation During Vaccine Development and Commercialization.
Patentable inventions may be made during the development of a vaccine, and patents on such inventions can help to protect the vaccine from competition. This chapter introduces several patent law… Expand