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Molecular characterization of a peripheral receptor for cannabinoids
The cloning of a receptor for cannabinoids is reported that is not expressed in the brain but rather in macrophages in the marginal zone of spleen, which helps clarify the non-psychoactive effects of cannabinoids.
Nuclear Translocation of Extradenticle Requires homothorax , which Encodes an Extradenticle-Related Homeodomain Protein
Generation of multiple antagonistic domains along the proximodistal axis during Drosophila leg development.
There exists in the leg disc a set of mutually antagonistic interactions between proximal cells, which are suggested to convert the WG and DPP activity gradients into discreet domains of gene expression along the proximodistal axis.
Control of the nuclear localization of Extradenticle by competing nuclear import and export signals.
Evidence is presented that, in the absence of Hth, Exd is exported from nuclei due to the activity of a nuclear export signal (NES), and it is proposed that in Exd there exists a balance between the activities of an NES and an NLS, and that Hth alters this balance in favor of the NLS.
Antagonism between extradenticle function and Hedgehog signalling in the developing limb
- S. González-Crespo, M. Abu-Shaar, M. Torres, C. Martínez-A, R. Mann, G. Morata
- 9 July 1998
It is shown that exd function and Dpp/Wg signalling are antagonistic and divide the leg into two mutually exclusive domains, and suggest that the division of the limb into two antagonistic domains, as defined by exd (Pbx1) function and Hh signalling, may be a general feature of limb development.
Nuclear import of the homeodomain protein Extradenticle in response to Wg and Dpp signalling
Evidence is presented that in the embryonic midgut both signalling pathways control the subcellular localization of the homeodomain protein encoded by the extradenticle (exd) gene.
Engrailed cooperates with extradenticle and homothorax to repress target genes in Drosophila
The functional requirements for extradenticle and homothorax beyond the Hox proteins to a larger family of non-Hox homeodomain proteins are expanded, and a model in which Engrailed, Extradenticles and Homothsorax function as a complex to repressEngrailed target genes is suggested.
From the Bench to the Pharmacy: Protecting Innovation During Vaccine Development and Commercialization.
This chapter introduces several patent law concepts, including patent eligible subject matter, written description, enablement, novelty, and nonobviousness, by following a hypothetical vaccine development timeline that begins with the discovery of a previously unknown virus and ends with the commercial launch of a vaccine against the virus.