• Publications
  • Influence
3'-functionalized adamantyl cannabinoid receptor probes.
The aliphatic side chain plays a pivotal role in determining the cannabinergic potency of tricyclic classical cannabinoids, and we have previously shown that this chain could be substitutedExpand
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Xenon Difluoride in Synthesis
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  • 1
Total Synthesis of Cryptophycins. Revision of the Structures of Cryptophycins A and C
The convergent total synthesis of cryptophycins C and D is described. It has been shown that in both natural products the absolute configuration of the a-amino acid corresponds to the D-series. TheExpand
  • 113
Some New Nazarov Chemistry
The Nazarov cyclization is a 4π-electron conrotatory cyclization of a pentadienyl cation that leads to a five-membered ring, typically a cyclopentenone. Because the mechanism is well defined, it isExpand
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Asymmetric Nazarov Cyclizations.
The Nazarov cyclization1 is described as the 4 π electron conrotatory cyclization of a pentadienyl cation. The past 20 years have brought resurgent interest in this reaction most likely due to theExpand
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Cationic cyclopentannelation of allene ethers.
  • M. A. Tius
  • Chemistry, Medicine
  • Accounts of chemical research
  • 30 January 2003
The variant of the Nazarov cyclization that makes use of allenyl ethers is suitable for the preparation of diverse, highly functionalized cyclopentenones. Three variants of the basic reaction,Expand
  • 147
Allene ether Nazarov cyclization.
  • M. A. Tius
  • Chemistry, Medicine
  • Chemical Society reviews
  • 7 April 2014
The ease of synthesis and the exceptional reactivity of alkoxyallenes has led to their use in a large number of highly diverse applications. This Report describes their use in various versions of theExpand
  • 104
Canventol inhibits tumor promotion in CD-1 mouse skin through inhibition of tumor necrosis factor alpha release and of protein isoprenylation.
A synthetic compound named canventol, 2-isopropyl-4-isopropylidencyclohex-2-ene-1-ol, inhibited tumor promotion of okadaic acid on mouse skin initiated with 7,12-dimethylbenz(a)anthracene inExpand
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An organocatalytic asymmetric Nazarov cyclization.
An organocatalytic asymmetric Nazarov cyclization of diketoesters that proceeds by means of a dual activation mechanism has been developed. Screening of a number of catalysts led to a new thioureaExpand
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