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- Publications
- Influence
Early biomarkers of stroke.
- M. A. Reynolds, H. J. Kirchick, +6 authors K. F. Buechler
- Medicine
- Clinical chemistry
- 1 October 2003
BACKGROUND
The diagnosis and management of acute ischemic stroke are limited by the lack of rapid diagnostic assays for use in an emergency setting. Computed tomography (CT) scanning is used to… Expand
Molecular alterations in prostate cancer.
- M. A. Reynolds
- Biology, Medicine
- Cancer letters
- 18 November 2008
Prostate tumors display a range of clinical phenotypes, from indolent to aggressively metastatic. Numerous gene expression profiling studies have been conducted toward the potential molecular staging… Expand
Antisense oligonucleotide containing an internal, non-nucleotide-based linker promote site-specific cleavage of RNA.
- M. A. Reynolds, T. A. Beck, +7 authors L. Arnold
- Biology, Medicine
- Nucleic acids research
- 1 February 1996
We have designed and synthesized a series of novel antisense methylphosphonate oligonucleotide (MPO) cleaving agents that promote site-specific cleavage on a complementary RNA target. These MPOs… Expand
Synthesis and thermodynamics of oligonucleotides containing chirally pure R(P) methylphosphonate linkages.
- M. A. Reynolds, R. Hogrefe, +9 authors L. Arnold
- Biology, Medicine
- Nucleic acids research
- 1 November 1996
Methylphosphonate (MP) oligodeoxynucleotides (MPOs) are metabolically stable analogs of conventional DNA containing a methyl group in place of one of the non-bonding phosphoryl oxygens. All 16… Expand
Molecular markers for prostate cancer.
- M. A. Reynolds, K. Kastury, J. Groskopf, J. Schalken, H. Rittenhouse
- Biology, Medicine
- Cancer letters
- 28 April 2007
Serum PSA testing has been used for over 20 years as an aid in the diagnosis and management of prostate cancer. Although highly sensitive, it suffers from a lack of specificity, showing elevated… Expand
An efficient binding chemistry for glass polynucleotide microarrays.
- P. H. Lee, S. Sawan, Z. Modrusan, L. Arnold, M. A. Reynolds
- Chemistry, Medicine
- Bioconjugate chemistry
- 2002
A variety of methods have been described for making synthetic polynucleotide microarrays. These include in situ synthesis directly on the array surface, for example, by photolithography or ink-jet… Expand
Molecular assays for the detection of prostate tumor derived nucleic acids in peripheral blood
- M. Jost, J. R. Day, +7 authors M. A. Reynolds
- Biology, Medicine
- Molecular Cancer
- 2 July 2010
BackgroundProstate cancer is the second leading cause of cancer mortality in American men. Although serum PSA testing is widely used for early detection, more specific prognostic tests are needed to… Expand
**1**5N AND **1**7O NMR STUDIES OF THE PROTON BINDING SITES IN IMIDODIPHOSPHATE, TETRAETHYL IMIDODIPHOSPHATE, AND ADENYLYL IMIDODIPHOSPHATE.
- M. A. Reynolds, J. Gerlt, P. Demou, N. Oppenheimer, G. L. Kenyon
- Chemistry
- 1 October 1983
Pour resoudre le probleme de la structure du pont P-N-P dans l'adenylyl-5p imidophosphate (AMP-PNP) en solution aqueuse, on utilise a la fois la spectrometrie RMN de 15 N et 17 O pour determiner le… Expand