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Early biomarkers of stroke.
BACKGROUND The diagnosis and management of acute ischemic stroke are limited by the lack of rapid diagnostic assays for use in an emergency setting. Computed tomography (CT) scanning is used toExpand
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Molecular alterations in prostate cancer.
Prostate tumors display a range of clinical phenotypes, from indolent to aggressively metastatic. Numerous gene expression profiling studies have been conducted toward the potential molecular stagingExpand
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Antisense oligonucleotide containing an internal, non-nucleotide-based linker promote site-specific cleavage of RNA.
We have designed and synthesized a series of novel antisense methylphosphonate oligonucleotide (MPO) cleaving agents that promote site-specific cleavage on a complementary RNA target. These MPOsExpand
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Synthesis and thermodynamics of oligonucleotides containing chirally pure R(P) methylphosphonate linkages.
Methylphosphonate (MP) oligodeoxynucleotides (MPOs) are metabolically stable analogs of conventional DNA containing a methyl group in place of one of the non-bonding phosphoryl oxygens. All 16Expand
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Molecular markers for prostate cancer.
Serum PSA testing has been used for over 20 years as an aid in the diagnosis and management of prostate cancer. Although highly sensitive, it suffers from a lack of specificity, showing elevatedExpand
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An efficient binding chemistry for glass polynucleotide microarrays.
A variety of methods have been described for making synthetic polynucleotide microarrays. These include in situ synthesis directly on the array surface, for example, by photolithography or ink-jetExpand
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Molecular assays for the detection of prostate tumor derived nucleic acids in peripheral blood
BackgroundProstate cancer is the second leading cause of cancer mortality in American men. Although serum PSA testing is widely used for early detection, more specific prognostic tests are needed toExpand
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Pour resoudre le probleme de la structure du pont P-N-P dans l'adenylyl-5p imidophosphate (AMP-PNP) en solution aqueuse, on utilise a la fois la spectrometrie RMN de 15 N et 17 O pour determiner leExpand
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