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Pentacyclic ingamine alkaloids, a new antiplasmodial pharmacophore from the marine sponge Petrosid Ng5 Sp5.
These polycyclic ingamine alkaloids represent the first example of antiplasmodial leads without a β-carboline ring, which is known to be responsible for the cytotoxicity of the well-known manzamine class of marine alkaloid related to 1-3.
ANTIVIRAL AND ANTIMICROBIAL ACTIVITIES OF SPIRULINA PLATENSIS
GC-MS analysis of the saponifiable and unsaponifiable fractions of the n-hexane extract besides the total carbohydrate, phenolic, flavonoid and tannin contents of the crude methanol extract were carried out.
Minor diterpene glycosides from the leaves of Stevia rebaudiana.
Two new diterpene glycoside in addition to five known glycosides have been isolated from a commercial extract of the leaves of Stevia rebaudiana, suggesting the newly isolated metabolites should be examined for their organoleptic properties.
Marine Inspired 2-(5-Halo-1H-indol-3-yl)-N,N-dimethylethanamines as Modulators of Serotonin Receptors: An Example Illustrating the Power of Bromine as Part of the Uniquely Marine Chemical Space
The in vitro data indicates that the antidepressant action exerted by these compounds in vivo is mediated, at least in part, via interaction with serotonin receptors, and shows the valuable role that bromine plays in providing novel chemical space and electrostatic interactions.
Induction of apoptosis and cell cycle arrest by Negombata magnifica sponge in hepatocellular carcinoma
The antiproliferative activity of Negombata magnifica was investigated as petroleum ether extract (PE), total methanolic extract (ME) and two sub-fractions II and III, isolated pure compounds (palmitic acid and pregnanediol), sponge mesohyl and primmorphs ethyl acetate extract.
Methicillin-resistant Staphylococcus aureus, Vancomycin-resistant Enterococcus faecalis and Enterococcus faecium active Dimeric Isobutyrylphloroglucinol from Ivesia gordonii
- Marwa H Ahmed, M. A. Ibrahim, I. Muhammad
- Chemistry, BiologyNatural product communications
- 1 February 2014
Bioassay-guided fractionation of the chloroform soluble fraction of stem, leaf, and flower extracts of the American plant Ivesia gordonii led to the isolation of a new dimeric acylphloroglucinol,…
Significance of endangered and threatened plant natural products in the control of human disease
- M. A. Ibrahim, M. Na, M. Hamann
- Environmental ScienceProceedings of the National Academy of Sciences
- 30 September 2013
A group of highly complex glycosides active against hepatitis C virus and a separate group of natural products active against established targets for the control of diabetes mellitus were found in the rare plant Diplostephium rhododendroides Hieron from the mountains of Ecuador.
Phytochemical study of Piliostigma thonningii, a medicinal plant grown in Nigeria
Phytochemical investigation of P. thonningii yielded two compounds newly isolated from natural sources, 2β-methoxyclovan-9α-ol and methyl-ent-3β-hydroxylabd-8(17)-en-15-oate, along with 14 known compounds, which suggested that hydroxylation at C-2 enhances the antiprotozoal activity towards T. brucei.
Rebaudiosides R and S, Minor Diterpene Glycosides from the Leaves of Stevia rebaudiana.
Two new diterpene glycosides have been isolated from a commercial extract of the leaves of Stevia rebaudiana and their structures were determined based on comprehensive 1D and 2D NMR studies.
2-N-Methyl modifications and SAR studies of manzamine A.