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Serotonin receptor sensitivity after acute and chronic treatment with mianserin.
- M. A. Blackshear, E. sanders-Bush
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 May 1982
The chronic administration of mianserin for 14 days leads to a marked decrease in the maximal number of serotonin2 (5-HT2) binding sites in brains of rats and mice with no change in the KD values.… Expand
Adaptive changes in the 5-HT2 binding site after chronic administration of agonists and antagonists
This study confirms and extends an earlier report that acute administration of the serotonin (5-HT) antagonist, mianserin, caused a marked decrease in the density of 5-HT2 binding sites in brain of… Expand
Multiple serotonin receptors: regional distribution and effect of Raphe lesions.
- M. A. Blackshear, L. Steranka, E. sanders-Bush
- Chemistry, Medicine
- European journal of pharmacology
- 17 December 1981
These studies confirm and extend the recent work suggesting that [3H]lysergic acid diethylamide (LSD) labels two distinct binding sites in rat brain resembling serotonin (5HT) receptors. Although… Expand
Acute and chronic effects of serotonin (5HT) antagonists on serotonin binding sites
- M. A. Blackshear, Roberta L. Friedman, E. sanders-Bush
- Biology, Medicine
- Naunyn-Schmiedeberg's Archives of Pharmacology
- 1 September 1983
SummaryThe administration of 14 daily doses of cyproheptadine, BC-105, metergoline and methysergide induced a marked decrease in the number (Bmax) of 3H-spiroperidol binding sites (5HT2 sites) in… Expand
Discriminative stimulus properties of l-5-hydroxytryptophan: Behavioral evidence for multiple serotonin receptors
Rats were trained to discriminate the stimulus properties of l-5-hydroxytryptophan (l-5-HTP) (30 mg/kg SC), the immediate precursor of serotonin (5-HT). The peripheral decarboxylase inhibitor… Expand
Effect of crowding on amphetamine-induced disaggregation of brain polyribosomes.
DL-amphetamine's actions on brain polyribosomes were studied in crowded and uncrowded mice. The administration of 20 mg/kg DL-amphetamine induced disaggregation of brain polyribosomes in both crowded… Expand