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PIK3CA mutation impact on survival in breast cancer patients and in ERα, PR and ERBB2-based subgroups
TLDR
PIK3CA mutation is an emerging tumor marker which might become used in treatment-choosing process and should be now confirmed in larger series of patients included in randomized prospective ERBB2-positive breast cancer patients.
PIK3R1 underexpression is an independent prognostic marker in breast cancer
TLDR
PIK3CA mutations and PIK3R1 underexpression show opposite effects on patient outcome and could become useful prognostic and predictive factors in breast cancer.
Outcome impact of PIK3CA mutations in HER2-positive breast cancer patients treated with trastuzumab
TLDR
The results confirm that the outcome of HER2-positive patients treated with trastuzumab is significantly worse in patients with PIK3CA-mutated compared with wild-type tumours.
Triple negative breast cancer--current status and prospective targeted treatment based on HER1 (EGFR), TOP2A and C-MYC gene assessment.
TLDR
The results suggest that particularly tumors with a complete pathological response to anthracyclines could have TOP2A amplification, which is associated with poor prognosis and hormonally negative breast carcinoma.
Gene Expression Profiling Reveals New Aspects of PIK3CA Mutation in ERalpha-Positive Breast Cancer: Major Implication of the Wnt Signaling Pathway
TLDR
A new gene set should help to understand the behavior of PIK3CA-mutated cancers and detailed knowledge of Wnt signaling activation could lead to novel therapeutic strategies.
Lapatinib in breast cancer - the predictive significance of HER1 (EGFR), HER2, PTEN and PIK3CA genes and lapatinib plasma level assessment.
TLDR
This minireview focuses on lapatinib and its role in breast cancer treatment and the focus is on efficacy assessment including predictive factors for therapy outcome.
Collagen triple helix repeat containing 1 protein, periostin and versican in primary and metastatic breast cancer: an immunohistochemical study
TLDR
Preliminary results show that combined evaluation of CTHRC1 and periostin could serve as a potential marker for breast cancer bone metastasis; the other observations contribute to the description of the tumour microenvironment, with implications for lymph node and bone metastases.
Gene Expression Profiling Reveals New Aspects of PIK 3 CA Mutation in ERalpha-Positive Breast Cancer : Major Implication of the Wnt Signaling Pathway
TLDR
A new gene set should help to understand the behavior of PIK3CA-mutated cancers and detailed knowledge of Wnt signaling activation could lead to novel therapeutic strategies.
High Lapatinib Plasma Levels in Breast Cancer Patients: Risk or Benefit?
TLDR
The lapatinib plasma levels reported here are twice as high as the clinically effective steady-state geometric mean maximum concentration, and attention should be paid to changes in liver function test results in clinical practice, especially in patients of small stature and weight, given the risk of high plasma concentrations.
Abstract P2-09-30: Impact ofPIK3CA,PTEN and RPS6 Status on Lapatinib Treatment Outcome in Advanced-Stage Breast Cancer Patients
TLDR
Results suggest a negative influence of PI3K/Akt pathway disregulation on disease prognosis and LC treatment response.
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