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  • Hidde J Haisma, E. P. Boven, M van Muijen, J. de Jong, W J Van der vijgh, Herbert Michael Pinedo
  • Medicine
  • British Journal of Cancer
  • 1992 (First Published: 1 September 1992)
  • The anti-pan carcinoma monoclonal antibody (MAb) 323/A3, linked to E. coli-derived beta-glucuronidase (GUS) was used to study the tumour-site-selective activation of the prodrugContinue Reading
  • Monique H. Vingerhoeds, Hidde J Haisma, M van Muijen, R B van de Rijt, Daan J. A. Crommelin, Gert Storm
  • Chemistry, Medicine
  • FEBS letters
  • 1993 (First Published: 28 December 1993)
  • We have tested a new type of immunoliposomes which may effectively mediate the targeting of enzymes to be used for site-specific prodrug activation (immuno-enzymosomes). The enzymeContinue Reading
  • Hidde J Haisma, M van Muijen, George Scheffer, Rik J. Scheper, Herbert Michael Pinedo, Epie Boven
  • Biology, Medicine
  • Hybridoma
  • 1995 (First Published: 1 August 1995)
  • The selectivity of anticancer agents may be improved by antibody-directed enzyme prodrug therapy (ADEPT). The immunogenicity of antibody-enzyme conjugates and the low tumor to normal tissue ratioContinue Reading