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80 It is well known that the background extracellular concentration of dopamine in the brain is below 0.1 μ M and only transiently increases to values of 1 μ M after activation of dopaminergic neurons [1]. The high-affinity Na-dependent dopamine transporter (DAT) and norepinephrine transporter (NET) are involved in the maintenance of the extracellular level(More)
65 One of important functions of astrocytes in the central nervous system (CNS) is the uptake of neuu rotransmitters released by neurons into the synaptic cleft. This uptake is mediated by specific transporters [1, 2]. In glutamatergic synapses, astrocytes return the transmitter back to neurons in the glutamate– glutamine cycle [3], and glutamate clearance(More)
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