Learn More
At least two forms of genomic instability have been described in colorectal cancers (CRCs): microsatellite instability (MIN), which is characterized by a high frequency of microsatellite instability (MSI-H) and chromosomal instability (CIN), which is characterized by losses and gains of chromosomes (aneuploidy), as well as chromosome rearrangements.(More)
Use of supercritical carbon dioxide extraction in the analysis of smokeless tobacco for tobacco-specific N-nitrosamines revealed the presence of higher levels of 4-(methylnitros-amino)-1-(3-pyridyl)-1-butanone (NNK) than had been determined with conventional methods. Whether human saliva may be similarly capable of releasing apparently bound NNK during(More)
To explore the relationship between mutations of the p53 gene, p53 protein accumulation in tumor tissues and the presence of anti-p53 antibodies (Ab) in sera, a matched case-control study with 63 colorectal cancer patients positive for p53-Ab was carried out. These control patients were matched for age, gender, as well as tumor site and stage with 63(More)
  • 1