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Labeled thymidine administered to adult rats is incorporated at a low level into brain DNA as shown by biochemical and autoradiographic methods. This incorporation takes place in part into neuronal nuclei and nucleoli and also into glial nuclei. While incorporation into glial nuclei is interpreted to represent known glial cell proliferation, incorporation(More)
The structure of the gene encoding the 14.5 kDa subunit of the human RNA polymerase II (or B) has been elucidated. The gene consists of six exons, ranging from 52 to over 101 bp, interspaced with five introns ranging from 84 to 246 bp. It is transcribed into three major RNA species, present at low abundance in exponentially growing HeLa cells. The(More)
Protein synthesis activity of poly(A) RNA from M1 neuroblastoma cells was studied in a reticulocyte cell-free system. The activity of poly(A) RNA from M1 cells "differentiated" morphologically by bromodeoxyuridine was compared with that of proliferating cells. Poly(A) RNA from differentiated cells was about 10% more active than the corresponding RNA from(More)
A study was made to compare alterations in the cerebral contents of nucleic acids and protein of several mouse strains affected by different neurological mutations: jimpy, msd, quaking, reeler, weaver, and dwarf. In normal and affected jimpy and msd mice the brain components analyzed were very similar. On the other hand, the cerebral hemispheres of quaking(More)
Free nucleotides in bromodeoxyuridine-treated neuroblastoma cells were investigated. The separation and purification of nucleotides were carried out by anion exchange and paper chromatography. After bromodeoxyuridine treatment, the distribution of free nucleotides with the same base, when referred to total nucleotides, shifted toward a distribution pattern(More)