M. Whitlock

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The therapeutic effects of centrally acting pharmaceuticals can manifest gradually and unreliably in patients, making the drug discovery process slow and expensive. Biological markers providing early evidence for clinical efficacy could help prioritize development of the more promising drug candidates. A potential source of such markers is functional(More)
PURPOSE To prospectively evaluate magnetic resonance (MR) imaging for the characterization of liver fibrosis by estimating fat and extracellular matrix content and hepatic perfusion parameters in CCl(4)-treated rats. MATERIALS AND METHODS The animal research protocol was approved by the Institutional Animal Care and Use Committee. Fifty-two rats (38(More)
Cases of head injury are reviewed in which riders wearing jockey skull caps have suffered impacts to the front, back or side of their helmets. The design and constructional materials of such helmets are assessed. Impact tests that simulate the accidents confirm the low energy absorption potential of some helmets for lateral impacts. Most pedal or motorcycle(More)
Several tablets are prepared with two forms of an active pharmaceutical ingredient (API) of which one (less than 1% w/w) is considered undesirable. The presence of this component is tested for by Raman microscopy in a series of mapping experiments. These experiments are conducted with a statistically based sampling routine in which the number of spectra to(More)
This is a study to fully assess a commercially available co-processed mannitol for its usefulness as an off-the-shelf excipient for developing orally disintegrating tablets (ODTs) by direct compression on a pilot scale (up to 4 kg). This work encompassed material characterization, formulation optimisation and process robustness. Overall, this co-processed(More)
A computational study was performed to determine the predictive capability of a Reynolds averaged Navier-Stokes code (CFL3D) for two-dimensional and three-dimensional multielement high-lift systems. Three configurations were analyzed: a three-element airfoil, a wing with a full span flap and a wing with a partial span flap. In order to accurately model(More)
Electrical power usage contributes significantly to the operational costs of large computer systems. At the Hypersonic Missile Technology Research and Operations Center (HMT-ROC) our system usage patterns provide a significant opportunity to reduce operating costs since there are a small number of dedicated users. The relatively predictable nature of our(More)
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